Potential fluid mechanic pathways of platelet activation.
Potential fluid mechanic pathways of platelet activation.
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DOI：
10.1007/s10237-012-0417-4
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发表时间：
2013-06
影响因子：
3.5
通讯作者：
Hendabadi, Sahar
中科院分区：
文献类型：
--
作者：
Shadden, Shawn C.;Hendabadi, Sahar
血小板活化是凝血的前体，在许多血管并发症和死亡原因中起主要作用。血小板可被化学或机械刺激激活。在机械上，血小板活化已被证明是升高的剪切应力和暴露时间的函数。这些贡献可以通过考虑血小板在运输时的累积应力或应变来组合。在这里，我们开发了一个框架，用于计算一个基于血流动力学的激活潜力，来自应变率幅度的拉格朗日积分。我们证明，这样的措施通常是最大化的沿着，并接近，在流动中的区别材料表面。激活电位和这些结构之间的连接说明通过狭窄流计算。我们发现了两种不同的结构，可以解释观察到的血栓形成的顶端和下游的狭窄。更广泛地说，这些研究结果表明，机械血小板活化的潜在流体力学途径和控制其运输的机制之间可能存在基本关系。
Platelet activation is a precursor for blood clotting, which plays leading roles in many vascular complications and causes of death. Platelets can be activated by chemical or mechanical stimuli. Mechanically, platelet activation has been shown to be a function of elevated shear stress and exposure time. These contributions can be combined by considering the cumulative stress or strain on a platelet as it is transported. Here we develop a framework for computing a hemodynamic-based activation potential that is derived from a Lagrangian integral of strain rate magnitude. We demonstrate that such a measure is generally maximized along, and near to, distinguished material surfaces in the flow. The connections between activation potential and these structures are illustrated through stenotic flow computations. We uncover two distinct structures that may explain observed thrombus formation at the apex and downstream of stenoses. More broadly, these findings suggest fundamental relationships may exist between potential fluid mechanic pathways for mechanical platelet activation and the mechanisms governing their transport.
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