Abnormal baseline brain activity in drug-naïve patients with Tourette syndrome: a resting-state fMRI study.
Abnormal baseline brain activity in drug-naïve patients with Tourette syndrome: a resting-state fMRI study.
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DOI：
10.3389/fnhum.2013.00913
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发表时间：
2014
影响因子：
2.9
通讯作者：
Zheng Y
中科院分区：
文献类型：
--
作者：
Cui Y;Jin Z;Chen X;He Y;Liang X;Zheng Y
多发性抽动症(TS)是一种儿童起病的慢性疾病，以多种运动和声带痉挛为特征。这项研究调查了TS患者在静息状态功能磁共振成像(Rs-fMRI)扫描过程中的自发低频波动。我们获得了17名药物天真的TS儿童和15名人口统计学上匹配的健康儿童的rS-fMRI扫描。计算rS-fMRI数据的低频波动幅度(Alff)和分数Alff(FALFF)以测量自发脑活动，并评估Alff/fALFF的组间差异以及Alff/fALFF与抽动严重程度评分的关系。结果显示，TS患儿扣带回后部/楔前回和双侧顶回的ALFF值明显降低。TS患儿前扣带回、双侧额中上叶和顶上叶FALFF降低，左侧壳核和双侧丘脑FALF值升高。此外，我们发现右侧丘脑的FALFF与抽动严重程度评分呈显著正相关。我们的研究为TS患者的神经元异常自发活动提供了经验证据，这可能涉及TS的潜在神经生理机制，并证明了将Alff/fALFF应用于临床TS研究的可能性。
Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated spontaneous low-frequency fluctuations in TS patients during resting-state functional magnetic resonance imaging (rs-fMRI) scans. We obtained rs-fMRI scans from 17 drug-naïve TS children and 15 demographically matched healthy children. We computed the amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) of rs-fMRI data to measure spontaneous brain activity, and assessed the between-group differences in ALFF/fALFF and the relationship between ALFF/fALFF and tic severity scores. Our results showed that the children with TS exhibited significantly decreased ALFF in the posterior cingulate gyrus/precuneus and bilateral parietal gyrus. fALFF was decreased in TS children in the anterior cingulated cortex, bilateral middle and superior frontal cortices and superior parietal lobule, and increased in the left putamen and bilateral thalamus. Moreover, we found significantly positive correlations between fALFF and tic severity scores in the right thalamus. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the underlying neurophysiological mechanism in TS and demonstrate the possibility of applying ALFF/fALFF for clinical TS studies.
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