Altered Functional Connectivity in Resting State Networks in Tourette's Disorder.
Altered Functional Connectivity in Resting State Networks in Tourette's Disorder.
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DOI：
10.3389/fnhum.2018.00363
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发表时间：
2018
影响因子：
2.9
通讯作者：
van der Werf YD
中科院分区：
文献类型：
--
作者：
Fan S;van den Heuvel OA;Cath DC;de Wit SJ;Vriend C;Veltman DJ;van der Werf YD
大脑各区域在解剖学和功能上相互联系，以促进认知和运动等重要功能。大脑连接如何影响妥瑞氏症（TD）的病理生理机制仍未完全了解。通过静息状态功能MRI，我们旨在确定与健康对照（HC）受试者相比，TD的默认模式网络（DMN）、额-顶叶网络（FPN）、感觉-运动网络（SMN）和显著性网络（SN）的变化。方法：对23例成年TD患者和22例HC患者进行3T-MRI静息状态扫描。独立成分分析比较了TD和HC，以研究静息状态网络内部和之间的连接模式。结果：与HC相比，TD患者在DMN连通性中表现出较高的背内侧前额叶皮层受累，而在FPN连通性中表现出较少的顶叶下皮层受累。此外，与HC相比，TD患者DMN与左FPN的耦合更强。最后，在TD患者中，DMN内的功能连通性与抽动严重程度呈负相关。结论：我们初步解释了TD患者DMN内功能连通性的增加是对左FPN内较低功能连通性的补偿。DMN和左FPN之间更强的耦合，以及DMN高的内在连通性与较低的抽动严重程度相关的发现，表明DMN被招募来施加运动抑制。
Introduction: Brain regions are anatomically and functionally interconnected in order to facilitate important functions like cognition and movement. It remains incompletely understood how brain connectivity contributes to the pathophysiology of Tourette’s disorder (TD). By using resting-state functional MRI, we aimed to identify alterations in the default mode network (DMN), frontal-parietal network (FPN), sensori-motor network (SMN), and salience network (SN) in TD compared with healthy control (HC) subjects. Method: In 23 adult TD patients and 22 HC, 3T-MRI resting-state scans were obtained. Independent component analysis was performed comparing TD and HC to investigate connectivity patterns within and between resting-state networks. Results: TD patients showed higher involvement of the dorsal medial prefrontal cortex in the connectivity of the DMN and less involvement of the inferior parietal cortex in the connectivity of the FPN when compared to HC. Moreover, TD patients showed a stronger coupling between DMN and left FPN than HC. Finally, in TD patients, functional connectivity within DMN correlated negatively with tic severity. Conclusion: We tentatively interpret the increased functional connectivity within DMN in TD patients as compensatory to the lower functional connectivity within left FPN. The stronger coupling between DMN and left FPN, together with the finding that higher DMN intrinsic connectivity is associated with lower tic severity would indicate that DMN is recruited to exert motor inhibition.
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影响因子：
3.6
作者：
Foa, EB;Huppert, JD;Salkovskis, PM
通讯作者：
Salkovskis, PM
影响因子：
11
作者：
Greene DJ;Williams Iii AC;Koller JM;Schlaggar BL;Black KJ;The Tourette Association of America Neuroimaging Consortium
通讯作者：
The Tourette Association of America Neuroimaging Consortium
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
14.5
作者：
Church, Jessica A.;Fair, Damien A.;Dosenbach, Nico U. F.;Cohen, Alexander L.;Miezin, Francis M.;Petersen, Steven E.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.
影响因子：
8.2
作者：
Cieslik, Edna C.;Mueller, Veronika I.;Eickhoff, Claudia R.;Langner, Robert;Eickhoff, Simon B.
通讯作者：
Eickhoff, Simon B.