Neural Mechanisms of Circadian Regulation of Natural and Drug Reward.
Neural Mechanisms of Circadian Regulation of Natural and Drug Reward.
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DOI：
10.1155/2017/5720842
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发表时间：
2017
影响因子：
3.1
通讯作者：
Logan RW
中科院分区：
文献类型：
--
作者：
DePoy LM;McClung CA;Logan RW
昼夜节律是生理和行为功能的近24小时变化由内源性产生的。在人类中，昼夜节律系统的紊乱与负面的健康后果有关，包括新陈代谢、免疫和精神疾病，如成瘾。动物模型表明，昼夜节律系统与滥用药物之间存在双向关系，因此，失去同步性、错位或干扰可能会促进药物使用的脆弱性和向成瘾的过渡，而暴露在滥用药物中可能会牵连、扰乱或扰乱昼夜节律系统。最近的证据表明，自然(即食物)和药物奖励可能会影响重叠的神经回路，而昼夜节律系统可能会调节对这些刺激的生理和行为反应。环境干扰，如改变时间表或更短/更长的白天，会影响食物和药物的摄取，控制细胞节律的某些昼夜节律基因突变与行为奖赏的改变有关。我们重点介绍了最近的发现，将昼夜节律与奖赏功能联系起来，将环境和遗传证据与自然和药物奖赏以及相关的神经回路联系起来。
Circadian rhythms are endogenously generated near 24-hour variations of physiological and behavioral functions. In humans, disruptions to the circadian system are associated with negative health outcomes, including metabolic, immune, and psychiatric diseases, such as addiction. Animal models suggest bidirectional relationships between the circadian system and drugs of abuse, whereby desynchrony, misalignment, or disruption may promote vulnerability to drug use and the transition to addiction, while exposure to drugs of abuse may entrain, disrupt, or perturb the circadian timing system. Recent evidence suggests natural (i.e., food) and drug rewards may influence overlapping neural circuitry, and the circadian system may modulate the physiological and behavioral responses to these stimuli. Environmental disruptions, such as shifting schedules or shorter/longer days, influence food and drug intake, and certain mutations of circadian genes that control cellular rhythms are associated with altered behavioral reward. We highlight the more recent findings associating circadian rhythms to reward function, linking environmental and genetic evidence to natural and drug reward and related neural circuitry.
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