Origin of the retroviruses: when, where, and how?
Origin of the retroviruses: when, where, and how?
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DOI：
10.1016/j.coviro.2017.06.006
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发表时间：
2017-08
影响因子：
5.9
通讯作者：
Hayward A
中科院分区：
文献类型：
--
作者：
Hayward A
逆转录病毒是具有相当重要的医学和兽医重要性的病毒家族。直到最近，人们对逆转录病毒的深层起源还知之甚少。新研究支持逆转录病毒起源于大约 460-5.5 亿年前的海洋。导致逆转录病毒起源的进化事件仍然不清楚。为此需要加深对后病毒科多样性和进化的了解。逆转录病毒是具有相当重要的医学和兽医重要性的病毒家族。此外，现在已经清楚内源性逆转录病毒（ERV）构成了脊椎动物基因组的重要部分。直到最近，人们对逆转录病毒的深层进化起源知之甚少。然而，基因组学和生物信息学的进步为理解的巨大进步开辟了道路。最近采用多种生物信息学方法的研究表明，逆转录病毒在 460 至 5.5 亿年前的古生代早期进化，为任何病毒组提供了最古老的推断日期估计。这一发现为研究导致逆转录病毒出现的进化转变提供了一个重要的框架，为了解主要病原病毒的感染起源提供了潜在的见解。
Retroviruses are a virus family of considerable medical and veterinary importance. Until recently, very little was known about deep retroviral origins. New research supports a marine origin of retroviruses, ∼460–550 million years ago. The evolutionary events leading to the origin of retroviruses remain obscure. Improved understanding of Metaviridae diversity and evolution are required for this. Retroviruses are a virus family of considerable medical and veterinary importance. Additionally, it is now clear that endogenous retroviruses (ERVs) comprise significant portions of vertebrate genomes. Until recently, very little was known about the deep evolutionary origins of retroviruses. However, advances in genomics and bioinformatics have opened the way for great strides in understanding. Recent research employing a wide variety of bioinformatic approaches has demonstrated that retroviruses evolved during the early Palaeozoic Era, between 460 and 550 million years ago, providing the oldest inferred date estimate for any virus group. This finding presents an important framework to investigate the evolutionary transitions that led to the emergence of the retroviruses, offering potential insights into the infectious origins of a major group of pathogenic viruses.
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影响因子：
3.8
作者：
Cui, Jie;Tachedjian, Gilda;Wang, Lin-Fa
通讯作者：
Wang, Lin-Fa
DOI：
10.1098/rstb.2012.0503
发表时间：
2013-09-19
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Lee A;Nolan A;Watson J;Tristem M
通讯作者：
Tristem M
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1073/pnas.1315419110
发表时间：
2013-12-10
影响因子：
11.1
作者：
Hayward, Alexander;Grabherr, Manfred;Jern, Patric
通讯作者：
Jern, Patric
在欧洲野兔（Lepus Europaeus）中鉴定了一个亲密的直系同源物，发现龙门型慢病毒的最低年龄为1200万。
影响因子：
3.7
作者：
Keckesova, Z.;Ylinen, L. M. J.;Towers, G. J.;Gifford, R. J.;Katzourakis, A.
通讯作者：
Katzourakis, A.