Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs).
Individual odour signatures that mice learn are shaped by involatile major urinary proteins (MUPs).
复制标题
DOI：
10.1186/s12915-018-0512-9
复制
发表时间：
2018-04-27
期刊：
影响因子：
5.4
通讯作者：
Hurst JL
中科院分区：
文献类型：
--
作者：
Roberts SA;Prescott MC;Davidson AJ;McLean L;Beynon RJ;Hurst JL
个体的可靠识别需要个体独特且随时间适当稳定的表型身份签名。在鸟类和一些哺乳动物中，个体特定的发声或视觉模式有很好的记录，而气味在许多脊椎动物和无脊椎动物的社会识别中起着关键作用。然而，人们还不太清楚的是，个体是否是通过个体之间各种各样的遗传和非遗传差异偶然产生的线索变化来识别的，或者动物是否进化出独特的多态信号来可靠地宣传身份。作为一种生物测定，以了解个人特定的气味签名的推导，我们使用女性的吸引力，男性家鼠（小家鼠）的个人气味，了解与男性的气味标记接触。习得的挥发性气味特征主要由非挥发性主要尿蛋白（MUP）特征的个体差异决定，MUP是小鼠在尿液中分泌的一组专门的通讯蛋白。在遗传上不同的小鼠识别气味签名依赖于个体MUP基因型的差异。使用重组MUP的直接操作证实了挥发性签名识别的可预测的变化，根据MUP配置文件和学习的尿液模板之间的匹配程度。这两个相对量的男性特定的MUP信息素darcin，诱导气味学习，和其他MUP亚型影响学习气味签名。相比之下，气味识别没有显着影响个别主要组织相容性复合体基因型。MUP配置文件形状挥发性气味签名通过异构体特异性差异的结合和释放尿挥发物的气味存款，这样的挥发性签名被识别从尿蛋白馏分单独。操纵使用重组MUP导致定量变化的释放已知的MUP配体的气味存款，MUP特定的和挥发性的影响。尽管假设许多基因对可用于识别个体的气味有贡献，但小鼠已经进化出一种多态组合MUP特征，可以在其气味中形成独特的挥发性特征。这种特定的信号可能比以前认识到的更普遍，有助于物种内表型多样性的进化。然而，选择的差异也可能导致物种特异性限制通过复杂的身体气味识别个体的能力。本文的在线版本（10.1186/s12915-018-0512-9）包含补充材料，可供授权用户使用。
Reliable recognition of individuals requires phenotypic identity signatures that are both individually distinctive and appropriately stable over time. Individual-specific vocalisations or visual patterning are well documented among birds and some mammals, whilst odours play a key role in social recognition across many vertebrates and invertebrates. Less well understood, though, is whether individuals are recognised through variation in cues that arise incidentally from a wide variety of genetic and non-genetic differences between individuals, or whether animals evolve distinctive polymorphic signals to advertise identity reliably. As a bioassay to understand the derivation of individual-specific odour signatures, we use female attraction to the individual odours of male house mice (Mus musculus domesticus), learned on contact with a male’s scent marks. Learned volatile odour signatures are determined predominantly by individual differences in involatile major urinary protein (MUP) signatures, a specialised set of communication proteins that mice secrete in their urine. Recognition of odour signatures in genetically distinct mice depended on differences in individual MUP genotype. Direct manipulation using recombinant MUPs confirmed predictable changes in volatile signature recognition according to the degree of matching between MUP profiles and the learned urine template. Both the relative amount of the male-specific MUP pheromone darcin, which induces odour learning, and other MUP isoforms influenced learned odour signatures. By contrast, odour recognition was not significantly influenced by individual major histocompatibility complex genotype. MUP profiles shape volatile odour signatures through isoform-specific differences in binding and release of urinary volatiles from scent deposits, such that volatile signatures were recognised from the urinary protein fraction alone. Manipulation using recombinant MUPs led to quantitative changes in the release of known MUP ligands from scent deposits, with MUP-specific and volatile-specific effects. Despite assumptions that many genes contribute to odours that can be used to recognise individuals, mice have evolved a polymorphic combinatorial MUP signature that shapes distinctive volatile signatures in their scent. Such specific signals may be more prevalent within complex body odours than previously realised, contributing to the evolution of phenotypic diversity within species. However, differences in selection may also result in species-specific constraints on the ability to recognise individuals through complex body scents. The online version of this article (10.1186/s12915-018-0512-9) contains supplementary material, which is available to authorized users.
登录
查看更多内容
DOI：
10.1007/bf01923448
发表时间：
1992-04-15
期刊：
EXPERIENTIA
影响因子：
--
作者：
BACCHINI, A;GAETANI, E;CAVAGGIONI, A
通讯作者：
CAVAGGIONI, A
影响因子：
2.9
作者：
Cheetham, Sarah A.;Smith, Abigail L.;Hurst, Jane L.
通讯作者：
Hurst, Jane L.
影响因子：
2.7
作者：
Brennan, Peter A.
通讯作者：
Brennan, Peter A.
影响因子：
4.6
作者：
Gouveia, Kelly;Hurst, Jane L.
通讯作者：
Hurst, Jane L.
影响因子：
4.6
作者：
Hurst JL;Beynon RJ;Armstrong SD;Davidson AJ;Roberts SA;Gómez-Baena G;Smadja CM;Ganem G
通讯作者：
Ganem G