Ultrasonic vocalizations, predictability and sensorimotor gating in the rat.
Ultrasonic vocalizations, predictability and sensorimotor gating in the rat.
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DOI：
10.1016/j.bbr.2013.07.013
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发表时间：
2013-09-15
影响因子：
2.7
通讯作者：
Cromwell, Howard C.
中科院分区：
文献类型：
--
作者：
Webber, Emily S.;Mankin, David E.;McGraw, Justin J.;Beckwith, Travis J.;Cromwell, Howard C.
前脉冲抑制（PPI）是包括人类在内的不同动物群体中感觉运动门控的量度。情绪状态可以影响人类的PPI，无论是在典型的受试者还是精神疾病患者中。很少有人知道情绪调节在PPI在啮齿动物。我们使用超声波发声记录监测大鼠在PPI测试期间的情绪状态。我们改变了PPI试验的可预测性，以检查门控和情绪调节的任何改变。我们还检查了PPI的动物选择性饲养的高或低水平的50 kHz USV发射。大鼠在整个PPI会话期间持续发出高水平的22 kHz呼叫。USV在PPI会话期间对前脉冲敏感，类似于惊吓。USV率是敏感的可预测性之间的不同水平的测试和重复的经验。惊吓和抑制惊吓不受可预测性以类似的方式。未发现PPI或惊吓的显著差异与不同水平的可预测性相关;然而，重复暴露后USV信号减少，PPI增强。与低水平和随机选择系相比，选择性饲养以排放高水平USV的动物在PPI会话期间排放显著更高水平的USV，并且ASR降低。总的来说，结果支持这样的想法，即PPI测试在啮齿动物中诱导高水平的负面影响，操纵动物的情绪风格改变门控会话的负面影响以及惊吓反应的强度。
Prepulse inhibition (PPI) is a measure of sensorimotor gating in diverse groups of animals including humans. Emotional states can influence PPI in humans both in typical subjects and in individuals with mental illness. Little is known about emotional regulation during PPI in rodents. We used ultrasonic vocalization recording to monitor emotional states in rats during PPI testing. We altered the predictability of the PPI trials to examine any alterations in gating and emotional regulation. We also examined PPI in animals selectively bred for high or low levels of 50 kHz USV emission. Rats emitted high levels of 22 kHz calls consistently throughout the PPI session. USVs were sensitive to prepulses during the PPI session similar to startle. USV rate was sensitive to predictability among the different levels tested and across repeated experiences. Startle and inhibition of startle were not affected by predictability in a similar manner. No significant differences for PPI or startle were found related the different levels of predictability; however, there was a reduction in USV signals and an enhancement of PPI after repeated exposure. Animals selectively bred to emit high levels of USVs emitted significantly higher levels of USVs during the PPI session and a reduced ASR compared to the low and random selective lines. Overall, the results support the idea that PPI tests in rodents induce high levels of negative affect and that manipulating emotional styles of the animals alters the negative impact of the gating session as well as the intensity of the startle response.
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影响因子：
2
作者：
Cromwell, Howard C.;Mears, Ryan P.;Boutros, Nash N.
通讯作者：
Boutros, Nash N.
影响因子：
3.6
作者：
Domeney, A;Feldon, J
通讯作者：
Feldon, J
DOI：
10.1037/h0031049
发表时间：
1971-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BADIA, P;CULBERTSON, S;LEWIS, P
通讯作者：
LEWIS, P
影响因子：
2.7
作者：
BADIA, P;HARSH, J;ABBOTT, B
通讯作者：
ABBOTT, B
影响因子：
2.7
作者：
Du, Yi;Wu, Xihong;Li, Liang
通讯作者：
Li, Liang