A Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility.
A Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility.
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DOI：
10.1093/aje/kwac011
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发表时间：
2022-07-23
影响因子：
5
通讯作者：
Wise LA
中科院分区：
文献类型：
--
作者：
Wesselink AK;Hatch EE;Rothman KJ;Wang TR;Willis MD;Yland J;Crowe HM;Geller RJ;Willis SK;Perkins RB;Regan AK;Levinson J;Mikkelsen EM;Wise LA
由于担心对生育能力产生潜在不利影响，一些育龄人士仍未接种 2019 年冠状病毒病 (COVID-19) 疫苗。我们利用基于互联网的孕前队列研究的数据，研究了尝试自然受孕的夫妇中，COVID-19 疫苗接种和严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染与生育能力的关系。我们招募了 2,126 名 2020 年 12 月至 2021 年 9 月期间居住在美国或加拿大、年龄在 21 至 45 岁之间的女性参与者，并对她们进行跟踪直至 2021 年 11 月。参与者每 8 周完成一次有关社会人口统计、生活方式、医疗因素和伴侣信息的调查问卷。我们拟合比例概率回归模型来估计双方自我报告的 COVID-19 疫苗接种与 SARS-CoV-2 感染与生育力（即每个周期受孕概率）之间的关联，并调整潜在的混杂因素。 COVID-19 疫苗接种与任一伴侣的生育能力均无显着相关性（女性生育能力比 (FR) = 1.08，95% 置信区间 (CI)：0.95, 1.23；男性 FR = 0.95，95% CI：0.83, 1.10）。女性 SARS-CoV-2 感染与生育能力没有很强的相关性（FR = 1.07，95% CI：0.87，1.31）。男性感染与生育能力暂时降低相关（对于60天内感染，FR = 0.82，95% CI：0.47，1.45；对于60天后感染，FR = 1.16，95% CI：0.92，1.47）。这些发现表明，男性 SARS-CoV-2 感染可能与生育能力的短期下降有关，并且 COVID-19 疫苗接种不会损害任何一方的生育能力。
Some reproductive-aged individuals remain unvaccinated against coronavirus disease 2019 (COVID-19) because of concerns about potential adverse effects on fertility. Using data from an internet-based preconception cohort study, we examined the associations of COVID-19 vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with fertility among couples trying to conceive spontaneously. We enrolled 2,126 self-identified female participants aged 21–45 year residing in the United States or Canada during December 2020–September 2021 and followed them through November 2021. Participants completed questionnaires every 8 weeks on sociodemographics, lifestyle, medical factors, and partner information. We fit proportional probabilities regression models to estimate associations between self-reported COVID-19 vaccination and SARS-CoV-2 infection in both partners with fecundability (i.e., the per-cycle probability of conception), adjusting for potential confounders. COVID-19 vaccination was not appreciably associated with fecundability in either partner (female fecundability ratio (FR) = 1.08, 95% confidence interval (CI): 0.95, 1.23; male FR = 0.95, 95% CI: 0.83, 1.10). Female SARS-CoV-2 infection was not strongly associated with fecundability (FR = 1.07, 95% CI: 0.87, 1.31). Male infection was associated with a transient reduction in fecundability (for infection within 60 days, FR = 0.82, 95% CI: 0.47, 1.45; for infection after 60 days, FR = 1.16, 95% CI: 0.92, 1.47). These findings indicate that male SARS-CoV-2 infection may be associated with a short-term decline in fertility and that COVID-19 vaccination does not impair fertility in either partner.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
6.7
作者：
Donders GGG;Bosmans E;Reumers J;Donders F;Jonckheere J;Salembier G;Stern N;Jacquemyn Y;Ombelet W;Depuydt CE
通讯作者：
Depuydt CE
影响因子：
4.4
作者：
King JP;McLean HQ;Belongia EA
通讯作者：
Belongia EA
影响因子：
2.4
作者：
Diaz, Parris;Reddy, Pritika;Ramasamy, Ranjith
通讯作者：
Ramasamy, Ranjith
影响因子：
6.1
作者：
Bentov, Y.;Beharier, O.;Klement, A. Hersko
通讯作者：
Klement, A. Hersko