Methamphetamine-induced behavioral sensitization in a rodent model of posttraumatic stress disorder.
Methamphetamine-induced behavioral sensitization in a rodent model of posttraumatic stress disorder.
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DOI：
10.1016/j.drugalcdep.2013.04.001
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发表时间：
2013-07-01
影响因子：
4.2
通讯作者：
Perrine SA
中科院分区：
文献类型：
--
作者：
Eagle AL;Perrine SA
单一长期应激（SPS）是一种具有创伤后应激障碍（PTSD）样特征的啮齿动物模型。鉴于创伤后应激障碍经常与物质滥用和依赖共病，包括甲基苯丙胺（METH），目前的研究试图调查SPS对甲基苯丙胺诱导的行为敏感化的影响。在实验1中，对Sprague-Dawley大鼠进行SPS或对照治疗，随后在四个阶段的逐步增加的METH给药模式中进行测试。注射METH（i. p.）以递增剂量（0、0.032、0.1、0.32、1.0和3.2 mg/kg;溶于盐水）每15分钟给药一次，并记录走动活动。在实验2中，将SPS和对照处理的大鼠注射（i. p.）用盐水或METH（5 mg/kg）连续5天每天给药，并测试刻板症以及行走活动。两天后，给所有动物注射激发剂量的METH（2.5 mg/kg），并再次检测活性。SPS和对照组之间对METH的急性反应无差异。与对照组相比，SPS增强了METH诱导的跨会话的走动活动。METH-induced刻板印象增加跨会话，行为敏化的指示;然而，SPS衰减，而不是增强，这种效果表明，SPS可以防止刻板印象敏化的发展。总的来说，结果表明，SPS增加重复的METH诱导的走动活动，同时防止跨会话从走动活动到刻板的过渡。这些研究结果表明，SPS改变药物诱导的神经可塑性与METH的行为敏化，这可能反映了对共同的神经回路的影响，潜在的创伤后应激障碍和物质依赖。
Single prolonged stress (SPS) is a rodent model of posttraumatic stress disorder (PTSD)-like characteristics. Given that PTSD is frequently comorbid with substance abuse and dependence, including methamphetamine (METH), the current study sought to investigate the effects of SPS on METH-induced behavioral sensitization. In experiment 1, Sprague-Dawley rats were subject to SPS or control treatment and subsequently tested across four sessions of an escalating METH dosing paradigm. METH was injected (i.p.) in escalating doses (0, 0.032, 0.1, 0.32, 1.0, and 3.2 mg/kg; dissolved in saline) every 15 mins and ambulatory activity was recorded. In experiment 2, SPS and control treated rats were injected (i.p.) with either saline or METH (5 mg/kg) for five consecutive daily sessions and tested for stereotypy as well as ambulatory activity. Two days later, all animals were injected with a challenge dose of METH (2.5 mg/kg) and again tested for activity. No differences in the acute response to METH were observed between SPS and controls. SPS enhanced METH induced ambulatory activity across sessions, compared to controls. METH-induced stereotypy increased across sessions, indicative of behavioral sensitization; however, SPS attenuated, not enhanced, this effect suggesting that SPS may prevent the development of stereotypy sensitization. Collectively, results show that SPS increases repeated METH-induced ambulatory activity while preventing the transition across sessions from ambulatory activity to stereotypy. These findings suggest that SPS alters drug-induced neuroplasticity associated with behavioral sensitization to METH, which may reflect an effect on the shared neurocircuitry underlying PTSD and substance dependence.
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影响因子：
2.7
作者：
Lowenberg, Mark;Stahn, Cindy;Buttgereit, Frank
通讯作者：
Buttgereit, Frank
DOI：
10.1186/1471-2210-6-6
发表时间：
2006-03-03
期刊：
BMC pharmacology
影响因子：
--
作者：
Han DD;Gu HH
通讯作者：
Gu HH
DOI：
10.1038/nrn3339
发表时间：
2012-11
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Pitman RK;Rasmusson AM;Koenen KC;Shin LM;Orr SP;Gilbertson MW;Milad MR;Liberzon I
通讯作者：
Liberzon I
影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
5
作者：
McGuire, Blaine A.;Baladi, Michelle G.;France, Charles P.
通讯作者：
France, Charles P.