Protective effects of carnosine on white matter damage induced by chronic cerebral hypoperfusion.
Protective effects of carnosine on white matter damage induced by chronic cerebral hypoperfusion.
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肌肽对慢性脑灌注不足引起的白质损伤的保护作用。
DOI：
10.4103/1673-5374.191217
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发表时间：
2016-09
影响因子：
6.1
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Ma J;Bo SH;Lu XT;Xu AJ;Zhang J
肌肽是一种清除自由基、抑制中枢神经系统炎症并通过其抗氧化和抗凋亡作用防止缺血性和缺氧性脑损伤的二肽。因此，我们假设肌肽也可以保护皮质下缺血性损伤引起的白色物质损伤。结扎小鼠右侧单侧颈总动脉造成白色物质损伤。在损伤前30分钟和损伤后每隔一天通过腹膜内注射200、500或750 mg/kg肌肽处理动物。然后，37天后，进行Klüver-Barrera染色、甲苯胺蓝染色和免疫荧光染色。肌肽（200、500 mg/kg）可显著减轻胼胝体、内囊和视束中白色物质的损伤，并可挽救髓鞘碱性蛋白的表达，减轻少突胶质细胞的丢失。然而，750 mg/kg的较高剂量的肌肽没有与200和500 mg/kg剂量相同的效果。这些发现表明，肌肽在特定剂量范围内保护小鼠免受慢性脑缺血引起的白色物质损伤，可能是通过减少少突胶质细胞损失。
Carnosine is a dipeptide that scavenges free radicals, inhibits inflammation in the central nervous system, and protects against ischemic and hypoxic brain damage through its anti-oxidative and anti-apoptotic actions. Therefore, we hypothesized that carnosine would also protect against white matter damage caused by subcortical ischemic injury. White matter damage was induced by right unilateral common carotid artery occlusion in mice. The animals were treated with 200, 500 or 750 mg/kg carnosine by intraperitoneal injection 30 minutes before injury and every other day after injury. Then, 37 days later, Klüver-Barrera staining, toluidine blue staining and immunofluorescence staining were performed. Carnosine (200, 500 mg/kg) substantially reduced damage to the white matter in the corpus callosum, internal capsule and optic tract, and it rescued expression of myelin basic protein, and alleviated the loss of oligodendrocytes. However, carnosine at the higher dose of 750 mg/kg did not have the same effects as the 200 and 500 mg/kg doses. These findings show that carnosine, at a particular dose range, protects against white matter damage caused by chronic cerebral ischemia in mice, likely by reducing oligodendroglial cell loss.
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影响因子：
48
作者：
Kalaria, Raj N.;Maestre, Gladys E.;Arizaga, Raul;Friedland, Robert P.;Galasko, Doug;Hall, Kathleen;Luchsinger, Jose A.;Ogunniyi, Adesola;Perry, Elaine K.;Potocnik, Felix;Prince, Martin;Stewart, Robert;Wimo, Anders;Zhang, Zhen-Xin;Antuono, Piero
通讯作者：
Antuono, Piero
影响因子：
1.7
作者：
Bandyopadhyay TK;Biswas A;Roy A;Guin DS;Gangopadhyay G;Sarkhel S;Ghoshal MK;Senapati AK
通讯作者：
Senapati AK
DOI：
10.11477/mf.1416200158
发表时间：
2015-04-01
期刊：
Brain and nerve = Shinkei kenkyu no shinpo
影响因子：
--
作者：
Hashimoto, Mamoru;Ikeda, Manabu
通讯作者：
Ikeda, Manabu
肌肽对小鼠皮质下缺血性血管性痴呆的保护作用
影响因子：
5.5
作者：
Ma, Jing;Xiong, Jia-Yan;Chen, Zhong
通讯作者：
Chen, Zhong
DOI：
10.1155/2015/764251
发表时间：
2015
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Park D;Shin K;Choi EK;Choi Y;Jang JY;Kim J;Jeong HS;Lee W;Lee YB;Kim SU;Joo SS;Kim YB
通讯作者：
Kim YB