Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia.
Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia.
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DOI：
10.4103/0972-2327.138520
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发表时间：
2014-07
影响因子：
1.7
通讯作者：
Senapati AK
中科院分区：
文献类型：
--
作者：
Bandyopadhyay TK;Biswas A;Roy A;Guin DS;Gangopadhyay G;Sarkhel S;Ghoshal MK;Senapati AK
本研究旨在比较阿尔茨海默病（AD）和血管性痴呆（VaD）患者的行为和精神症状（BPSD）。我们使用国家神经和交流障碍研究所和中风阿尔茨海默病及相关疾病协会诊断AD的标准和国家神经疾病研究所和中风协会国际pour la Recherche et l 'Enseignement en Neurosciences诊断VaD的标准。VaD队列进一步细分为小血管和大血管疾病。分别采用临床痴呆评定量表（CDR）和神经精神量表研究认知障碍的严重程度和BPSD。我们研究了50例AD和50例VaD患者，其中38例为小血管VaD，12例为大血管VaD。两组痴呆症的严重程度相当。VaD患者的激越/攻击、抑郁/烦躁、焦虑、冷漠/冷漠、易怒、异常运动行为、食欲和进食行为以及夜间行为的发生率显著高于AD患者。我们发现两个队列中每例患者的CDR评分和神经精神症状数量之间存在弱正相关。与小血管VaD相比，大血管VaD患者的兴奋/欣快、激越/攻击明显更频繁。BPSD在两种类型的痴呆中都很常见，当两组具有相似的认知障碍水平时，VaD比AD更严重。
The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD) in patients of Alzheimer disease (AD) and vascular dementia (VaD). We used National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for diagnosing AD and National Institute of Neurological Disorders and Stroke-Association International pour la Recherche et l’Enseignement en Neurosciences Criteria for diagnosing VaD. VaD cohort was further subcategorized into small vessel and large vessel disease. The severity of cognitive impairment and the BPSD were studied by means of the Clinical Dementia Rating Scale (CDR) and the Neuropsychiatric Inventory respectively. We studied 50 AD and 50 VaD patients of whom 38 were small vessels and 12 were large vessels VaD. The severity of dementia was comparable in both groups. The agitation/aggression, depression/dysphoria, anxiety, apathy/indifference, irritability, aberrant motor behavior, appetite and eating behavior and night-time behaviors occurred significantly more frequently in patients with VaD than AD. We found a weak positive correlation between the CDR score and the number of neuropsychiatric symptoms per patient in both cohorts. Elation/euphoria, agitation/aggression was significantly more frequent in patients with large vessel in comparison to small vessel VaD. BPSD are common in both types of dementia and they are more severe in VaD than AD when the groups have similar levels of cognitive impairment.
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影响因子：
1.7
作者：
Gupta M;Dasgupta A;Khwaja GA;Chowdhury D;Patidar Y;Batra A
通讯作者：
Batra A
影响因子：
7
作者：
Thompson, Claire;Brodaty, Henry;Sachdev, Perminder
通讯作者：
Sachdev, Perminder
记忆衰退连续体中神经精神症状的患病率：记忆诊所环境中的观察性研究
影响因子：
2.3
作者：
Zhang M;Wang H;Li T;Yu X
通讯作者：
Yu X
DOI：
10.1111/j.1532-5415.1984.tb02233.x
发表时间：
1984-01-01
影响因子：
6.3
作者：
BUCHT, G;ADOLFSSON, R;WINBLAD, B
通讯作者：
WINBLAD, B
影响因子：
3.1
作者：
Shaji, S;Bose, Srija;Kuriakose, Shan
通讯作者：
Kuriakose, Shan