Increases in functional connectivity between prefrontal cortex and striatum during category learning.
Increases in functional connectivity between prefrontal cortex and striatum during category learning.
复制标题
DOI：
10.1016/j.neuron.2014.05.005
复制
发表时间：
2014-07-02
期刊：
影响因子：
16.2
通讯作者：
Miller EK
中科院分区：
文献类型：
--
作者：
Antzoulatos EG;Miller EK
Functional connectivity between the prefrontal cortex (PFC) and striatum (STR) is thought critical for cognition, and has been linked to conditions like autism and schizophrenia. We recorded from multiple electrodes in PFC and STR while monkeys acquired new categories. Category learning was accompanied by an increase in beta-band synchronization of LFPs between, but not within, the PFC and STR. After learning, different pairs of PFC-STR electrodes showed stronger synchrony for one or the other category, suggesting category-specific functional circuits. This category-specific synchrony was also seen between PFC spikes and STR LFPs, but not the reverse, reflecting the direct monosynaptic connections from the PFC to STR. However, causal connectivity analyses suggested that the polysynaptic connections from STR to the PFC exerted a stronger overall influence. This supports models positing that the basal ganglia “train” the PFC. Category learning may depend on the formation of functional circuits between the PFC and STR.
登录
查看更多内容
DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
DOI：
10.1111/ejn.12453
发表时间：
2014-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Cannon J;McCarthy MM;Lee S;Lee J;Börgers C;Whittington MA;Kopell N
通讯作者：
Kopell N
影响因子：
56.9
作者：
Buschman, Timothy J.;Miller, Earl K.
通讯作者：
Miller, Earl K.
影响因子：
16.2
作者：
Arnsten AF;Wang MJ;Paspalas CD
通讯作者：
Paspalas CD
影响因子：
3.3
作者：
LYNDBALTA, E;HABER, SN
通讯作者：
HABER, SN