Association between plasma trans-fatty acid concentrations and diabetes in a nationally representative sample of US adults.
Association between plasma trans-fatty acid concentrations and diabetes in a nationally representative sample of US adults.
复制标题
DOI：
10.1111/1753-0407.12652
复制
发表时间：
2018-08
影响因子：
4.5
通讯作者：
Bao W
中科院分区：
文献类型：
--
作者：
Liu B;Sun Y;Snetselaar LG;Sun Q;Yang Q;Zhang Z;Liu L;Hu FB;Bao W
在啮齿动物模型和灵长类动物的实验研究中，高反式脂肪酸(TFA)饮食诱导了胰岛素抵抗。然而，以前关于反式脂肪酸(TFA)与糖尿病之间关系的流行病学研究，主要基于自我报告的饮食摄入量，得出了相互矛盾的结果。我们在美国成年人中进行了一项大规模的基于人群的研究，研究了客观测量的血浆TFA浓度与糖尿病的相关性。我们纳入了3801名年龄在20岁或以上的参与者，这些参与者来自1999-2000年和2009-2010年的国家健康和营养检查调查。用气相色谱-质谱法测定了空腹血浆中棕榈酸(C16：1n-7t)、榄香酸(C18：1n-9t)、万古酸(C18：1n-7t)和亚麻酸(C18：2n-6t，9t)四种主要脂肪酸。糖尿病的定义是医生自己报告的诊断，空腹血糖≥126 mg/dL，或糖化血红蛋白(HbA1c)≥6.5%。调整其他主要危险因素后，糖尿病与血浆总脂肪酸的比值比(OR)分别为2.19(95%可信区间，1.27~3.79)、2.34(1.48~3.72)、1.33(0.82~2.15)、1.58(0.97~2.58)、和1.64(0.95~2.84)(趋势0.09)。此外，总脂肪酸、榄香酸、棕榈酸和牛油酸与空腹血糖、空腹胰岛素、胰岛素抵抗指数和糖化血红蛋白显著相关。在具有全国代表性的人群中，血浆总脂肪酸，特别是伊莱迪酸，与糖尿病和葡萄糖代谢的生物标志物呈正相关。
High trans fatty acid (TFA) diet induces insulin resistance in experimental studies in rodent models and primates. However, previous epidemiological studies on the association between trans fatty acids (TFAs), mainly based on self-reported intake from diet, and diabetes have yielded conflicting results. We examined the associations of objectively-measured plasma TFA concentrations with diabetes in a large population-based study among U.S. adults. We included 3,801 participants aged 20 years or older from the National Health and Nutrition Examination Survey 1999–2000 and 2009–2010. Four major TFAs, including palmitelaidic acid (C16:1n-7t), elaidic acid (C18:1n-9t), vaccenic acid (C18:1n-7t), and linolelaidic acid (C18:2n-6t, 9t), were measured in fasting plasma using gas chromatography-mass spectrometry. Diabetes was defined by self-reported physician diagnosis, plasma fasting glucose ≥ 126 mg/dL, or glycated hemoglobin (HbA1c) ≥ 6.5%. After adjustment for other major risk factors, the odds ratio (OR) of diabetes comparing the highest with lowest quintile of plasma TFAs was 2.19 (95% CI, 1.27–3.79) for total TFAs (P for trend 0.01), 2.34 (1.48–3.72) for elaidic acid (P for trend 0.0004), 1.33 (0.82–2.15) for linolelaidic acid (P for trend 0.18), 1.58 (0.97–2.58) for palmitelaidic acid (P for trend 0.02), and 1.64 (0.95–2.84) for vaccenic acid (P for trend 0.09). In addition, total TFAs, elaidic acid, palmitelaidic acid, and vaccenic acid were significantly associated with fasting glucose, fasting insulin, insulin resistance index, and HbA1c. In a nationally representative population, plasma TFAs, in particular elaidic acid, were positively associated with diabetes and biomarkers of glucose metabolism.
登录
查看更多内容
影响因子：
5.8
作者：
Saravanan, N;Haseeb, A;Ghafoorunissa
通讯作者：
Ghafoorunissa
影响因子：
120.7
作者：
Menke, Andy;Casagrande, Sarah;Cowie, Catherine C.
通讯作者：
Cowie, Catherine C.
影响因子：
7.1
作者：
Mozaffarian, D;Pischon, T;Rimm, EB
通讯作者：
Rimm, EB
DOI：
10.3945/an.114.007690
发表时间：
2015-05
期刊：
Advances in nutrition (Bethesda, Md.)
影响因子：
--
作者：
Pasin G;Comerford KB
通讯作者：
Comerford KB
影响因子：
5
作者：
Demmer, Ryan T.;Zuk, Aleksandra M.;Desvarieux, Moise
通讯作者：
Desvarieux, Moise