A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses.
A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses.
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DOI：
10.1371/journal.pone.0051957
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Leng Q
中科院分区：
文献类型：
--
作者：
Wei R;Yang C;Zeng M;Terry F;Zhu K;Yang C;Altmeyer R;Martin W;De Groot AS;Leng Q
CD4+T细胞介导的免疫在确定病毒感染的免疫发病机制中起着核心作用。然而，CD4+T细胞在导致手足口病的EV71感染中的作用尚不清楚。我们应用了一种复杂的方法来识别包含在EV71多蛋白序列中的混杂的CD4+T细胞表位。共鉴定出15个表位，其中3个为优势表位。最主要的表位在肠道病毒物种中高度保守，包括与手足口病相关的柯萨奇病毒、与手足口病无关的ECHO病毒和脊髓灰质炎病毒。此外，针对该表位的CD4+T细胞确实与脊髓灰质炎病毒3Sabin的同源物发生交叉反应。我们的发现表明，接种脊髓灰质炎病毒后的CD4+T细胞反应，或儿童早期可能接触的其他肠道病毒，可能对随后的EV71感染或疫苗的CD4+T细胞反应具有调节作用。
CD4+ T cell-mediated immunity plays a central role in determining the immunopathogenesis of viral infections. However, the role of CD4+ T cells in EV71 infection, which causes hand, foot and mouth disease (HFMD), has yet to be elucidated. We applied a sophisticated method to identify promiscuous CD4+ T cell epitopes contained within the sequence of the EV71 polyprotein. Fifteen epitopes were identified, and three of them are dominant ones. The most dominant epitope is highly conserved among enterovirus species, including HFMD-related coxsackieviruses, HFMD-unrelated echoviruses and polioviruses. Furthermore, the CD4+ T cells specific to the epitope indeed cross-reacted with the homolog of poliovirus 3 Sabin. Our findings imply that CD4+ T cell responses to poliovirus following vaccination, or to other enteroviruses to which individuals may be exposed in early childhood, may have a modulating effect on subsequent CD4+ T cell response to EV71 infection or vaccine.
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DOI：
10.1084/jem.181.4.1285
发表时间：
1995-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mahon BP;Katrak K;Nomoto A;Macadam AJ;Minor PD;Mills KH
通讯作者：
Mills KH
影响因子：
5.4
作者：
KUTUBUDDIN, M;SIMONS, J;CHOW, M
通讯作者：
CHOW, M
影响因子：
5.4
作者：
LECLERC, C;DERIAUD, E;VANDERWERE, S
通讯作者：
VANDERWERE, S
影响因子：
5.4
作者：
Brown, BA;Oberste, MS;Pallansch, MA
通讯作者：
Pallansch, MA
影响因子：
2.6
作者：
Fujimoto, T;Chikahira, M;Nishio, O
通讯作者：
Nishio, O