The effect of psychostimulants on skeletal health in boys co-treated with risperidone.
The effect of psychostimulants on skeletal health in boys co-treated with risperidone.
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DOI：
10.1016/j.jpeds.2015.03.005
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发表时间：
2015-06
影响因子：
5.1
通讯作者：
Zemel, Babette S.
中科院分区：
文献类型：
--
作者：
Calarge, Chadi A.;Schlechte, Janet A.;Burns, Trudy L.;Zemel, Babette S.
探讨儿童和青少年慢性精神兴奋剂治疗对骨骼的影响。医学上健康的5 - 17岁男性来自4个不同的临床研究。他们按精神兴奋剂的使用情况分为3组：无至可忽略，间歇和持续使用。大多数（95%）患者同时接受利培酮治疗6个月或更长时间。从医疗和药房记录中提取治疗史。在每次研究访问时，使用双能x线吸收仪（DXA）和外周定量计算机断层扫描（pQCT）进行人体测量和骨骼测量。多变量线性回归分析模型检验了三个精神兴奋剂使用组中年龄性别特异性身高z得分和骨骼结果是否存在差异。样本包括194名男性，研究开始时平均年龄为11.7±2.8岁。大多数人有外化障碍。三个治疗组在身高z评分或桡骨、腰椎或全身骨骼结果方面没有显著差异。144名男孩在研究开始后1.4±0.7年有有效的随访骨骼数据。同样，在两次访问期间继续使用精神兴奋剂的人，重新开始使用精神兴奋剂的人，或者没有服用精神兴奋剂的人，身高z分数和骨骼结果都没有差异。长期治疗后，精神兴奋剂对服用利培酮的儿童和青少年骨量的增加似乎没有显著影响。对纵向生长有较小但统计上不显著的负影响。
To examine the skeletal effects of chronic psychostimulant treatment in children and adolescents. Medically healthy 5 to 17 year-old males from four different clinic-based studies were combined for this analysis. They were divided by psychostimulant use into 3 groups: none to negligible, intermittent, and continuous use. Most (95%) had also received risperidone for six months or more. Treatment history was extracted from medical and pharmacy records. Anthropometric and bone measurements, using dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT), were obtained at each research visit. Multivariable linear regression analysis models examined whether age-sex-specific height Z-score and skeletal outcomes differed among the three psychostimulant-use groups. The sample consisted of 194 males with a mean age of 11.7±2.8 years at study entry. The majority had an externalizing disorder. There was no significant difference across the three treatment groups in height Z-score or in skeletal outcomes at the radius, lumbar spine, or whole body. One hundred forty-four boys had valid follow-up skeletal data 1.4±0.7 years after study entry. Again, neither height Z-score nor the skeletal outcomes were different among those who remained on psychostimulants between the two visits, started psychostimulants anew, or had not taken psychostimulants. Following chronic treatment, psychostimulants did not appear to significantly affect bone mass accrual in children and adolescents taking risperidone. There was a small, but statistically not significant, negative impact on longitudinal growth.
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影响因子：
2.6
作者：
Bruckner, Tim A.;Hodgson, Ashley;Scheffler, Richard M.
通讯作者：
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DOI：
10.1097/00004583-200001000-00014
发表时间：
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DOI：
10.1097/chi.0b013e318054e724
发表时间：
2007-07-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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