Detection of SARS-CoV-2 in Milk From COVID-19 Positive Mothers and Follow-Up of Their Infants.
Detection of SARS-CoV-2 in Milk From COVID-19 Positive Mothers and Follow-Up of Their Infants.
复制标题
DOI：
10.3389/fped.2020.597699
复制
发表时间：
2020
影响因子：
2.6
通讯作者：
Collaborative Research Group on SARS-CoV-2 in Human Milk
中科院分区：
文献类型：
--
作者：
Bertino E;Moro GE;De Renzi G;Viberti G;Cavallo R;Coscia A;Rubino C;Tonetto P;Sottemano S;Campagnoli MF;Soldi A;Mostert M;Cresi F;Lembo D;Collaborative Research Group on SARS-CoV-2 in Human Milk
背景：在目前的SARS冠状病毒2（SARS-CoV-2）大流行中，对母乳中的SARS-CoV-2知之甚少。重要的是要发现母乳是否是感染的媒介。目的：我们的目的是寻找SARS-CoV-2 RNA在一组来自意大利西北部的SARS-CoV-2阳性母亲的乳汁中的存在。研究方法：这是一项前瞻性合作观察性研究，收集了14名SARS-CoV-2阳性母乳母亲的母乳样本。通过检测人乳的RT-PCR（实时逆转录酶聚合酶链反应）方法搜索母乳样本中的病毒RNA。所有新生儿在出生后的第一个月内或直到发现两个连续的阴性拭子进行临床随访。结果：13例患者乳汁中SARS-CoV-2 RNA检测结果为阴性，1例为阳性。14名新生儿中有13名在出生后的第一个月内完全接受母乳喂养并受到密切监测。临床结局无事件。4名新生儿的SARS-CoV-2检测呈阳性，均在出生后48小时内，即母亲出现症状后检测到。此外，这4名婴儿（包括接受SARS-CoV-2阳性母乳的婴儿）的临床过程也很顺利，并且所有婴儿在出生后6周内均呈SARS-CoV-2阴性。结论：我们的研究支持这样的观点，即SARS-CoV-2阳性母亲不会通过母乳喂养使新生儿暴露于额外的感染风险。
Background: In the current SARS-Coronavirus-2 (SARS-CoV-2) pandemic little is known about SARS-CoV-2 in human milk. It is important to discover if breast milk is a vehicle of infection. Objective: Our aim was to look for the presence of SARS-CoV-2 RNA in the milk of a group of SARS-CoV-2 positive mothers from North-West Italy. Methods: This is a prospective collaborative observational study where samples of human milk from 14 breastfeeding mothers positive for SARS-CoV-2 were collected. A search of viral RNA in breast milk samples was performed by RT-PCR (Real-Time reverse-transcriptase-Polymerase-Chain-Reaction) methodology tested for human milk. All the newborns underwent a clinical follow up during the first month of life or until the finding of two sequential negative swabs. Results: In 13 cases the search for SARS-CoV-2 RNA in milk samples resulted negative and in one case it was positive. Thirteen of the 14 newborns were exclusively breastfed and closely monitored in the first month of life. Clinical outcome was uneventful. Four newborns tested positive for SARS-CoV-2 and were all detected in the first 48 h of life, after the onset of maternal symptoms. Also the clinical course of these 4 infants, including the one who received mother's milk positive for SARS-CoV-2, was uneventful, and all of them became SARS-CoV-2 negative within 6 weeks of life. Conclusion: Our study supports the view that SARS-CoV-2 positive mothers do not expose their newborns to an additional risk of infection by breastfeeding.
登录
查看更多内容
影响因子：
11.8
作者：
Wang, Shaoshuai;Guo, Lili;Feng, Ling
通讯作者：
Feng, Ling
影响因子：
168.9
作者：
Chen, Huijun;Guo, Juanjuan;Zhang, Yuanzhen
通讯作者：
Zhang, Yuanzhen
影响因子：
6.4
作者：
Cui, Yuxia;Tian, Maolu;Zha, Yan
通讯作者：
Zha, Yan
DOI：
10.1007/s10096-008-0505-7
发表时间：
2008-09-01
影响因子：
4.5
作者：
Gagneur, A.;Dirson, E.;Payan, C.
通讯作者：
Payan, C.
DOI：
10.1111/1471-0528.16276
发表时间：
2020-05-26
影响因子：
5.8
作者：
Wu, Y.;Liu, C.;Huang, H.
通讯作者：
Huang, H.