Impact of Erythromycin as a Prokinetic on the Gut Microbiome in Children with Feeding Intolerance-A Pilot Study.
Impact of Erythromycin as a Prokinetic on the Gut Microbiome in Children with Feeding Intolerance-A Pilot Study.
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DOI：
10.3390/antibiotics12111606
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发表时间：
2023-11-08
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影响因子：
--
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中科院分区：
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背景：研究表明，当全身使用抗生素时，肠道微生物群会发生变化。关于长期使用琥珀酸红霉素乙酯(EES)作为促动力药物时对肠道微生物群的影响的文献很少。方法：对接受EES(N=8)的喂养不耐受患儿的粪便标本进行细菌群和真菌菌群分析。年龄匹配、临床特征相似但未接受EES治疗的儿童作为对照组(N=20)。结果：两组细菌种类以变形杆菌、拟杆菌和变形杆菌为最多。真菌种类最丰富的是子囊菌门，其次是担子菌门。细菌和真菌微生物群的丰富度在两组之间没有显著差异。细菌和真菌微生物组的α多样性(属和种水平)和β多样性(属水平)没有显著差异。在物种水平上，各组间真菌微生物区系差异显著，p值为0.029。我们还注意到，在EES组中，许多真菌微生物在属和种水平上都显著高于对照组。结论：在这项观察性病例对照研究中，EES的促动力使用与菌群组在物种水平上的β多样性的变化有关。与对照组相比，EES组的许多真菌微生物数量显著增加。在更大规模的试验中证实这些结果将提供进一步的证据，证明当EES被用作促动剂时，对肠道微生物区系的影响。
Background: Studies have demonstrated that the gut microbiome changes upon exposure to systemic antibiotics. There is a paucity of literature regarding impact on the gut microbiome by long-term usage of erythromycin ethyl succinate (EES) when utilized as a prokinetic. Methods: Stool samples from pediatric patients with feeding intolerance who received EES (N = 8) as a prokinetic were analyzed for both bacteriome and mycobiome. Age-matched children with similar clinical characteristics but without EES therapy were included as controls (N = 20). Results: In both groups, Proteobacteria, Firmicutes, and Bacteroidetes were the most abundant bacterial phyla. Ascomycota was the most abundant fungal phyla, followed by Basidiomycota. There were no significant differences in richness between the groups for both bacterial and fungal microbiome. Alpha diversity (at genus and species levels) and beta diversity (at the genus level) were not significantly different between the groups for both bacterial and fungal microbiome. At the species level, there was a significant difference between the groups for fungal microbiota, with a p-value of 0.029. We also noted that many fungal microorganisms had significantly higher p-values in the EES group than controls at both genera and species levels. Conclusions: In this observational case-control study, the prokinetic use of EES was associated with changes in beta diversity between the groups for mycobiome at the species level. Many fungal microorganisms were significantly higher in the EES group when compared to the controls. Confirmation of these results in larger trials will provide further evidence regarding the impact of EES on gut microbiota when utilized as a prokinetic agent.
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影响因子：
6.4
作者：
Ghannoum M
通讯作者：
Ghannoum M
影响因子：
3.8
作者：
Bai, J.;Hu, Y.;Bruner, D. W.
通讯作者：
Bruner, D. W.
影响因子：
6.4
作者：
Boutin RCT;Sbihi H;McLaughlin RJ;Hahn AS;Konwar KM;Loo RS;Dai D;Petersen C;Brinkman FSL;Winsor GL;Sears MR;Moraes TJ;Becker AB;Azad MB;Mandhane PJ;Subbarao P;Turvey SE;Finlay BB
通讯作者：
Finlay BB
影响因子：
4.9
作者：
Azad, M. B.;Bridgman, S. L.;Kozyrskyj, A. L.
通讯作者：
Kozyrskyj, A. L.
DOI：
10.3390/jof8101046
发表时间：
2022-10-04
期刊：
Journal of fungi (Basel, Switzerland)
影响因子：
--
作者：
Belvoncikova P;Splichalova P;Videnska P;Gardlik R
通讯作者：
Gardlik R