The Human Mycobiome: Colonization, Composition and the Role in Health and Disease.
The Human Mycobiome: Colonization, Composition and the Role in Health and Disease.
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DOI：
10.3390/jof8101046
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发表时间：
2022-10-04
期刊：
影响因子：
--
通讯作者：
Gardlik R
中科院分区：
文献类型：
--
作者：
Belvoncikova P;Splichalova P;Videnska P;Gardlik R
真菌生物群系是人类微生物生态系统的真菌组成部分，仅代表该环境的一小部分，但在维持体内平衡方面发挥着重要作用。真菌在出生后立即开始定植。最初的真菌群落受到新生儿的胎龄、出生体重、分娩方式和喂养方式的影响。在人的一生中，真菌生物群系的组成进一步受到大量内源性和外源性因素的影响。最重要的因素是饮食，体重，年龄，性别和抗生素和抗真菌治疗。人类真菌群落栖息于口腔、胃肠道、呼吸道、泌尿生殖道和皮肤。其组成可通过免疫和非免疫介导的串扰系统影响肠-脑轴。它还通过协同和拮抗关系与生态系统的其他生物相互作用。此外，免疫受损个体中机会性真菌病原体在肠道的定殖可导致临床相关疾病状态。因此，真菌组代表了与各种生理和病理过程相关的微生物组的重要部分。这篇综述总结了目前对人体特定部位真菌生物群系组成及其在健康和疾病中的作用的认识。
The mycobiome is the fungal component of the human microbial ecosystem that represents only a small part of this environment but plays an essential role in maintaining homeostasis. Colonization by fungi begins immediately after birth. The initial mycobiome is influenced by the gestational age of a newborn, birth weight, delivery method and feeding method. During a human’s life, the composition of the mycobiome is further influenced by a large number of endogenous and exogenous factors. The most important factors are diet, body weight, age, sex and antibiotic and antifungal therapy. The human mycobiome inhabits the oral cavity, gastrointestinal tract, respiratory tract, urogenital tract and skin. Its composition can influence the gut–brain axis through immune and non-immune mediated crosstalk systems. It also interacts with other commensals of the ecosystem through synergistic and antagonistic relationships. Moreover, colonization of the gut by opportunistic fungal pathogens in immunocompromised individuals can lead to clinically relevant disease states. Thus, the mycobiome represents an essential part of the microbiome associated with a variety of physiological and pathological processes. This review summarizes the current knowledge on the composition of the mycobiome in specific sites of the human body and its role in health and disease.
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DOI：
10.1016/j.diagmicrobio.2010.04.005
发表时间：
2011-08-01
影响因子：
2.9
作者：
Chen, Yu;Chen, Zhenjing;Li, Lanjuan
通讯作者：
Li, Lanjuan
影响因子：
4.6
作者：
Burcham, Zachary M.;Garneau, Nicole L.;Metcalf, Jessica L.
通讯作者：
Metcalf, Jessica L.
影响因子：
24.5
作者：
Coker, Olabisi Oluwabukola;Nakatsu, Geicho;Yu, Jun
通讯作者：
Yu, Jun
影响因子：
3.7
作者：
Carpagnano, Giovanna Elisiana;Susca, Antonia;Barbaro, Maria Pia Foschino
通讯作者：
Barbaro, Maria Pia Foschino
影响因子：
3.3
作者：
DARWAZEH, AMG;ALBASHIR, A
通讯作者：
ALBASHIR, A