Advances in Fucoxanthin Research for the Prevention and Treatment of Inflammation-Related Diseases.
Advances in Fucoxanthin Research for the Prevention and Treatment of Inflammation-Related Diseases.
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岩藻黄质防治炎症相关疾病的研究进展
DOI：
10.3390/nu14224768
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发表时间：
2022-11-11
期刊：
影响因子：
5.9
通讯作者：
Su, Jingqian
中科院分区：
文献类型：
--
作者：
Guan, Biyun;Chen, Kunsen;Tong, Zhiyong;Chen, Long;Chen, Qi;Su, Jingqian
岩藻黄质（FX）是一种类胡萝卜素，由于其独特的结构和性质，引起了人们的广泛关注。有许多研究表明FX的抗炎，抗氧化，抗肿瘤和抗肥胖特性对炎症相关疾病。然而，关于这种现象背后的分子机制还没有达成共识。本文从动物实验和细胞实验两个方面综述了FX在炎症相关疾病中的潜在健康益处，以期为FX的进一步研究提供参考。我们实验室以前的工作已经证明，FX显着降低LPS诱导的炎症，提高脓毒症小鼠的存活率。FX对多种疾病的活性的进一步研究将需要新的方法来揭示其分子机制。本次审查将提供一个关于FX应用在临床环境中的知识的现状的大纲，并建议未来的方向，以实现FX作为药物科学的治疗成分，以发展成为一种治疗策略，对炎症相关疾病。
Owing to its unique structure and properties, fucoxanthin (FX), a carotenoid, has attracted significant attention. There have been numerous studies that demonstrate FX’s anti-inflammatory, antioxidant, antitumor, and anti-obesity properties against inflammation-related diseases. There is no consensus, however, regarding the molecular mechanisms underlying this phenomenon. In this review, we summarize the potential health benefits of FX in inflammatory-related diseases, from the perspective of animal and cellular experiments, to provide insights for future research on FX. Previous work in our lab has demonstrated that FX remarkably decreased LPS-induced inflammation and improved survival in septic mice. Further investigation of the activity of FX against a wide range of diseases will require new approaches to uncover its molecular mechanism. This review will provide an outline of the current state of knowledge regarding FX application in the clinical setting and suggest future directions to implement FX as a therapeutic ingredient in pharmaceutical sciences in order to develop it into a treatment strategy against inflammation-associated disorders.
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