Microfluidic Devices for Drug Delivery Systems and Drug Screening.
Microfluidic Devices for Drug Delivery Systems and Drug Screening.
复制标题
DOI：
10.3390/genes9020103
复制
发表时间：
2018-02-16
期刊：
影响因子：
3.5
通讯作者：
Kodzius R
中科院分区：
文献类型：
--
作者：
Damiati S;Kompella UB;Damiati SA;Kodzius R
微流控器件在开发高效的药物载体颗粒、无细胞蛋白质合成系统和直接药物筛选的快速技术方面具有独特的优势。与整体方法相比，微流控技术通过有效地控制芯片的几何形状和多相流体的流速，能够产生高度稳定、均匀、单分散的颗粒，并具有更高的包封率。由于现有的临床前模型是预测临床结果的低效药物筛选，微流控平台可能提供一种更快速、更具成本效益的替代方案。与2D细胞培养系统和体内动物模型相比，微流控3D平台以一种简单、廉价的方式模拟体内细胞系统，从而实现了在细胞、器官和全身水平上的高通量和多重药物筛选。在这篇综述中，重点介绍了使用不同配置的微流控装置来产生包括不同颗粒类型的合适的药物或基因载体。此外，本文讨论了制造的微流控无细胞蛋白质合成系统的出现，这些系统可能在护理点使用，以及作为智能、敏感和可重复的芯片上的细胞、器官和人类模型，允许在模拟生物系统的条件下研究药物的效果。
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates of multiphase fluids, microfluidic technology enables the generation of highly stable, uniform, monodispersed particles with higher encapsulation efficiency. Since the existing preclinical models are inefficient drug screens for predicting clinical outcomes, microfluidic platforms might offer a more rapid and cost-effective alternative. Compared to 2D cell culture systems and in vivo animal models, microfluidic 3D platforms mimic the in vivo cell systems in a simple, inexpensive manner, which allows high throughput and multiplexed drug screening at the cell, organ, and whole-body levels. In this review, the generation of appropriate drug or gene carriers including different particle types using different configurations of microfluidic devices is highlighted. Additionally, this paper discusses the emergence of fabricated microfluidic cell-free protein synthesis systems for potential use at point of care as well as cell-, organ-, and human-on-a-chip models as smart, sensitive, and reproducible platforms, allowing the investigation of the effects of drugs under conditions imitating the biological system.
登录
查看更多内容
影响因子：
4
作者：
Chokkalingam, Venkatachalam;Herminghaus, Stephan;Seemann, Ralf
通讯作者：
Seemann, Ralf
影响因子：
5.8
作者：
Chung, TW;Huang, YY;Liu, YZ
通讯作者：
Liu, YZ
影响因子：
10.8
作者：
Champion, Julie A.;Katare, Yogesh K.;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
12.6
作者：
Bernacka-Wojcik, Iwona;Lopes, Paulo;Martins, Rodrigo
通讯作者：
Martins, Rodrigo
DOI：
10.1038/mtna.2012.28
发表时间：
2012-08-14
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
通讯作者：
--