Magnetic Particle Imaging (MPI): Experimental Quantification of Vascular Stenosis Using Stationary Stenosis Phantoms.
Magnetic Particle Imaging (MPI): Experimental Quantification of Vascular Stenosis Using Stationary Stenosis Phantoms.
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DOI：
10.1371/journal.pone.0168902
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Haegele J
中科院分区：
文献类型：
--
作者：
Vaalma S;Rahmer J;Panagiotopoulos N;Duschka RL;Borgert J;Barkhausen J;Vogt FM;Haegele J
磁粒子成像(MPI)具有时间分辨率高、空间分辨率好、信噪比高、灵敏度高等优点。此外，它是一种真正的定量方法，因为它的信号强度与其示踪剂超顺磁性氧化铁纳米颗粒(SPIO)的浓度成正比。正因为如此，MPI被认为是一种很有前途的心血管成像方法。在这里，一个有趣的应用可能是通过利用SPIO浓度和MPI信号强度的比例来量化血管病变，如狭窄。在本研究中，基于这一应用场景，评估了基于MPI的狭窄量化的可行性。用1%Resovist稀释液填充9个正常管腔直径为10 mm的不同狭窄模体和1~9 mm不同狭窄管腔，10个直径为1~10 mm的参比管模，在临床前MPI演示仪上进行测量。比较参考模体的MPI信号强度，并利用每个狭窄模体内信号强度的变化来计算狭窄程度。然后将这些值与每个体模的已知直径进行比较。作为第二次测量，使用5 mm狭窄模体进行一系列稀释度测量，直到1：3200(0.031%)的Resovist稀释度，这低于平均成年人外周动脉中Resovist丸剂的第一次血液浓度至少约1：1000。基于MPI信号强度测量的狭窄值与基于已知直径的狭窄值之间的相关性非常好，证明了定量MPI在这方面的高精度。
Magnetic Particle Imaging (MPI) is able to provide high temporal and good spatial resolution, high signal-to-noise ratio and sensitivity. Furthermore, it is a truly quantitative method as its signal strength is proportional to the concentration of its tracer, superparamagnetic iron oxide nanoparticles (SPIOs). Because of that, MPI is proposed to be a promising future method for cardiovascular imaging. Here, an interesting application may be the quantification of vascular pathologies like stenosis by utilizing the proportionality of the SPIO concentration and the MPI signal strength. In this study, the feasibility of MPI based stenosis quantification is evaluated based on this application scenario. Nine different stenosis phantoms with a normal diameter of 10 mm each and different stenoses of 1–9 mm and ten reference phantoms with a straight diameter of 1–10 mm were filled with a 1% Resovist dilution and measured in a preclinical MPI-demonstrator. The MPI signal intensities of the reference phantoms were compared to each other and the change of signal intensity within each stenosis phantom was used to calculate the degree of stenosis. These values were then compared to the known diameters of each phantom. As a second measurement, the 5 mm stenosis phantom was used for a serial dilution measurement down to a Resovist dilution of 1:3200 (0.031%), which is lower than a first pass blood concentration of a Resovist bolus in the peripheral arteries of an average adult human of at least about 1:1000. The correlation of the stenosis values based on MPI signal intensity measurements and based on the known diameters showed a very good agreement, proving the high precision of quantitative MPI in this regard.
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影响因子：
19.7
作者：
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通讯作者：
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作者：
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通讯作者：
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