Computer-controlled stimulation for functional magnetic resonance imaging studies of the neonatal olfactory system.
Computer-controlled stimulation for functional magnetic resonance imaging studies of the neonatal olfactory system.
复制标题
DOI：
10.1111/apa.12327
复制
发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Edwards AD
中科院分区：
文献类型：
--
作者：
Arichi T;Gordon-Williams R;Allievi A;Groves AM;Burdet E;Edwards AD
研究表明，嗅觉在人类新生儿早期就具有很高的功能，气味可以影响婴儿的行为和母婴关系。由于其良好的空间特性，血氧水平依赖（BOLD）对比功能磁共振成像（fMRI）有可能迅速推进我们对这一关键时期嗅觉感知发展基础的神经活动的理解。我们的目标是设计一种“嗅觉计”，专门用于新生儿受试者的气味感知功能磁共振成像研究。方法我们描述了一个完全自动化的、可编程的、功能磁共振成像兼容的系统，能够呈现有气味的液体。为了防止系统污染并尽量减少受试者之间的感染风险，大多数嗅觉仪由一次性使用的、现成的临床设备构成。该系统被用于呈现婴儿配方奶的气味，验证组7名新生儿受试者在足月后年龄（中位年龄40周）。结果一种安全、可靠、可重复的刺激模式在梨状皮质、杏仁核、丘脑、岛叶皮质和小脑中产生了定位良好的阳性BOLD功能反应。结论该系统适用于人类早期大脑发育过程中嗅觉感知本体的详细研究。
Aim Olfactory sensation is highly functional early in human neonatal life, with studies suggesting that odours can influence behaviour and infant–mother bonding. Due to its good spatial properties, blood oxygen level–dependent (BOLD) contrast functional magnetic resonance imaging (fMRI) has the potential to rapidly advance our understanding of the neural activity which underlies the development of olfactory perception in this key period. We aimed to design an ‘olfactometer’ specifically for use with neonatal subjects for fMRI studies of odour perception. Methods We describe a fully automated and programmable, fMRI compatible system capable of presenting odorant liquids. To prevent contamination of the system and minimize between-subject infective risk, the majority of the olfactometer is constructed from single-use, readily available clinical equipment. The system was used to present the odour of infant formula milk in a validation group of seven neonatal subjects at term equivalent postmenstrual age (median age 40 weeks). Results A safe, reliable and reproducible pattern of stimulation was delivered leading to well-localized positive BOLD functional responses in the piriform cortex, amygdala, thalamus, insular cortex and cerebellum. Conclusions The described system is therefore suitable for detailed studies of the ontology of olfactory sensation and perception during early human brain development.
登录
查看更多内容
影响因子：
5.7
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
通讯作者：
Edwards, A. David
影响因子：
2.9
作者：
Best, AR;Wilson, DA
通讯作者：
Wilson, DA
影响因子：
3.8
作者：
Schneider, Nanette Y.;Fletcher, Terrence P.;Renfree, Marilyn B.
通讯作者：
Renfree, Marilyn B.
影响因子：
--
作者：
Gassert, Roger;Burdet, Etienne;Chinzei, Kiyoyuki
通讯作者：
Chinzei, Kiyoyuki
影响因子：
3
作者：
Johnson, Bradley N.;Sobel, Noam
通讯作者：
Sobel, Noam