A Split-Face, Single-Blinded, Randomized Controlled Comparison of 532 nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser versus 532 nm Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Solar Lentigines.
A Split-Face, Single-Blinded, Randomized Controlled Comparison of 532 nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser versus 532 nm Q-Switched Neodymium-Doped Yttrium Aluminum Garnet Laser in the Treatment of Solar Lentigines.
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DOI：
10.5021/ad.2020.32.1.8
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发表时间：
2020-02
影响因子：
1.6
通讯作者：
Kim WS
中科院分区：
文献类型：
--
作者：
Kim JY;Yang J;Huh G;Choi YJ;Kim WS
太阳扁豆是最常见的良性表皮色素沉着，在韩国也是主要的美容问题之一。532 nm调Q激光通常用于治疗，但炎症后色素沉着(PIH)的发生并不罕见。最近，为了追求更好的结果，出现了皮秒(PS)激光的使用。目的：客观比较532 nm PS激光和QSND激光治疗太阳晶状体的疗效和安全性。20名患有太阳能晶状体的患者参加了一项前瞻性、随机、双面、单盲研究。每面一侧用532 nm PS激光治疗，另一侧用532 nm QSND激光治疗。治疗1次后，分别于2、4、8、12周进行随访评估。临床清晰度由三位盲人皮肤科医生使用5分位数改善量表(QIS)进行评估。同时记录患者的主观满意度、妊高征进展情况、治疗过程中的疼痛程度和不良反应。QIS测量的临床清晰度表明，PS激光比QSND激光更有效。两组患者的主观满意度和疼痛程度差异无统计学意义。PS激光治疗侧妊高征发生率为5%，QSND激光治疗侧妊高征发生率为30%。532 nm PS激光和QSND激光治疗日光性晶状体眼均有效，但PS激光治疗效果更好，妊高征发生率较低。
Solar lentigines are the most common form of benign epidermal pigmentation and one of the major cosmetic concerns in Korea. A 532 nm Q-switched neodymium: yttrium-aluminum-garnet (QSND) laser is typically used for the treatment, but the occurrence of post-inflammatory hyperpigmentation (PIH) is not rare. Recently, the use of picosecond (PS) lasers has emerged in pursuit of better outcomes. To objectively compare the efficacy and safety of 532 nm PS and QSND lasers for the treatment of solar lentigines. Twenty patients with solar lentigines were enrolled in a prospective, randomized split-face, single-blind study. One side of each face was treated using a 532 nm PS laser, and the other side using a 532 nm QSND laser. After one treatment, all patients were followed up for evaluation after 2, 4, 8, and 12 weeks. The clinical clearance was assessed by three blinded dermatologists using a 5-point quartile improvement scale (QIS). Subjective satisfaction, development of PIH, pain scale during treatment, and adverse problems were also recorded. Clinical clearance measured by QIS showed that the PS laser was more effective than the QSND laser. Subjective satisfaction and pain scale did not significantly differ between the two groups. The incidence of PIH was 5% in sides treated with the PS laser, and 30% with the QSND laser. Both 532 nm PS laser and QSND laser were effective for the treatment of solar lentigines, but the PS laser was more effective with less PIH development.
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影响因子：
6.5
作者：
ANDERSON, RR;MARGOLIS, RJ;DOVER, JS
通讯作者：
DOVER, JS
DOI：
10.1111/j.1468-3083.2011.04385.x
发表时间：
2013-03-01
影响因子：
9.2
作者：
Negishi, K.;Akita, H.;Matsunaga, K.
通讯作者：
Matsunaga, K.
影响因子：
2.4
作者：
Chan, HH;Fung, WKK;Kono, T
通讯作者：
Kono, T
影响因子：
2.4
作者：
Ho, S. G. Y.;Yeung, C. K.;Chan, H. H. L.
通讯作者：
Chan, H. H. L.
影响因子：
--
作者：
Todd, MM;Rallis, TM;Hata, TR
通讯作者：
Hata, TR