Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows.
Effects of erythrocyte deformability and aggregation on the cell free layer and apparent viscosity of microscopic blood flows.
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DOI：
10.1016/j.mvr.2009.01.010
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发表时间：
2009-05
影响因子：
3.1
通讯作者：
Popel AS
中科院分区：
文献类型：
--
作者：
Zhang J;Johnson PC;Popel AS
浓缩红细胞（即，采用浸入边界格子Boltzmann算法模拟了微通道中红细胞悬浮液的流动，研究了细胞层的形成过程以及细胞变形和聚集对血液动力学和血液流变学行为的影响。细胞被建模为二维可变形的双凹胶囊和实验测量的细胞特性已被利用。细胞之间的聚集是由一个莫尔斯潜力。流动发展过程展示了红细胞如何从边界向通道中心迁移，而悬浮的血浆流体被转移到迁移细胞留下的无细胞层区域。实验观察到的微观血流的几个重要特征已经很好地再现在我们的模型中，包括无细胞层，钝的速度分布，表观粘度的变化，和Fahraeus效应。我们发现，无细胞层的厚度增加与细胞变形能力和聚集强度。由于无细胞层润滑和细胞聚集核的高粘度的相反作用，聚集的影响是复杂的，但。润滑效应似乎占主导地位，导致相对表观粘度随着聚集而降低。因此，浸没边界格子玻尔兹曼数值模型可能是有用的，在各种微循环情况下的微观血流提供有价值的信息。
Concentrated erythrocyte (i.e., red blood cell) suspensions flowing in microchannels have been simulated with an immersed-boundary lattice Boltzmann algorithm, to examine the cell layer development process and the effects of cell deformability and aggregation on hemodynamic and hemorheological behaviors. The cells are modeled as two-dimensional deformable biconcave capsules and experimentally measured cell properties have been utilized. The aggregation among cells is modeled by a Morse potential. The flow development process demonstrates how red blood cells migrate away from the boundary toward the channel center, while the suspending plasma fluid is displaced to the cell free layer regions left by the migrating cells. Several important characteristics of microscopic blood flows observed experimentally have been well reproduced in our model, including the cell free layer, blunt velocity profile, changes in apparent viscosity, and the Fahraeus effect. We found that the cell free layer thickness increases with both cell deformability and aggregation strength. Due to the opposing effects of the cell free layer lubrication and the high viscosity of cell-concentrated core, the influence of aggregation is complex but. The lubrication effect appears to dominate, causing the relative apparent viscosity to decrease with aggregation. It appears therefore that the immersed-boundary lattice Boltzmann numerical model may be useful in providing valuable information on microscopic blood flows in various microcirculation situations.
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影响因子：
2.4
作者：
Kim, S;Kong, RL;Johnson, PC
通讯作者：
Johnson, PC
影响因子：
3.1
作者：
EVANS, E;FUNG, YC
通讯作者：
FUNG, YC
DOI：
10.1002/jss.400010418
发表时间：
1973-01-01
期刊：
Journal of Supramolecular Structure
影响因子：
--
作者：
CHIEN S;JAN K-M
通讯作者：
JAN K-M
影响因子：
3.4
作者：
Neu, B;Meiselman, HJ
通讯作者：
Meiselman, HJ
影响因子：
1.1
作者：
Murata, T
通讯作者：
Murata, T