Variation in rostral anterior cingulate functional connectivity with amygdala and caudate during first manic episode distinguish bipolar young adults who do not remit following treatment.
Variation in rostral anterior cingulate functional connectivity with amygdala and caudate during first manic episode distinguish bipolar young adults who do not remit following treatment.
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第一次躁狂发作期间与杏仁核和尾状的前扣带回的功能连通性的变化区分了双极年轻人，他们在治疗后未屈服的年轻人。
DOI：
10.1111/bdi.13025
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发表时间：
2021-08
影响因子：
5.4
通讯作者：
Strakowski SM
中科院分区：
文献类型：
--
作者：
Lippard ETC;Weber W;Welge J;Adler CM;Fleck DE;Almeida J;DelBello MP;Strakowski SM
此前曾报道过，在患有双相情感障碍的青少年第一次躁狂发作期间，腹外侧前额叶和前扣带皮层以及皮层下和杏仁核投射部位的活动发生了改变，并观察到与治疗反应有关。为了扩展这些发现，我们研究了在治疗八周后缓解的首发躁狂参与者与未缓解的参与者中这些区域之间的功能连接。招募了 42 名首次躁狂发作期间患有双相情感障碍的参与者（60% 为女性），并接受了八周的治疗。二十一人在治疗后病情缓解。参与者在基线和八周治疗后完成了功能磁共振成像扫描，同时在情绪和中性干扰因素下执行连续的表现任务。健康对照组（n=41）以相同的时间间隔接受功能磁共振成像评估。对基线时杏仁核和尾状核与头侧前扣带皮层和腹外侧前额叶皮质的功能连接差异（以及治疗后功能连接的变化）进行建模。在基线时，与健康参与者相比，非缓解者的右前扣带回和尾状核之间的正连接增加，而右前扣带回和杏仁核之间的负连接丢失。治疗后缓解的个体在治疗后八周显示杏仁核和左前扣带回之间的负连接增加。结果提供了双相情感障碍非缓解者在第一次躁狂发作期间前扣带回杏仁核和尾状核功能连接变化的证据，以及与缓解相关的前扣带回功能连接的变化，提示了预测治疗反应的目标。在 ClinicalTrials.Gov 注册；首发双相躁狂的大脑功能和神经化学变化。 NCT00609193。网址：https://clinicaltrials.gov/ct2/show/NCT00609193?term=strakowski&rank=1
Altered activity in the ventrolateral prefrontal and anterior cingulate cortices, as well as subcortical and amygdala projection sites, were previously reported during a first manic episode in youth with bipolar disorder and observed to be associated with treatment response. To extend these findings, we investigated functional connectivity among these regions in first-episode manic participants who remitted after eight weeks of treatment compared to those that did not. Forty-two participants with bipolar disorder (60% female) during their first manic episode were recruited and received eight weeks of treatment. Twenty-one remitted following treatment. Participants completed fMRI scans, at baseline and following eight weeks of treatment, while performing a continuous performance task with emotional and neutral distractors. A healthy comparison group (n=41) received fMRI evaluations at the same intervals. Differences in functional connectivity of the amygdala and caudate with the rostral anterior cingulate and ventrolateral prefrontal cortices at baseline (and changes in functional connectivity following treatment) were modeled between groups. At baseline, non-remitters showed an increase in positive connectivity between right anterior cingulate and caudate and a loss of negative connectivity between right anterior cingulate and amygdala, compared to healthy participants. Individuals who remitted following treatment showed an increase in negative connectivity between amygdala and left anterior cingulate eight weeks following treatment. Results provide evidence of alterations in anterior cingulate-amygdala and caudate functional connectivity in bipolar disorder non-remitters during a first manic episode and changes in anterior cingulate functional connectivity associated with remission suggesting targets to predict treatment response. Registered at ClinicalTrials.Gov; Functional and Neurochemical Brain Changes in First-episode Bipolar Mania. NCT00609193. URL: https://clinicaltrials.gov/ct2/show/NCT00609193?term=strakowski&rank=1
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影响因子：
2.6
作者：
Altamura, Alfredo Carlo;Buoli, Massimiliano;Dell'Osso, Bernardo
通讯作者：
Dell'Osso, Bernardo
影响因子：
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作者：
Blumberg, HP;Leung, HC;Peterson, BS
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Peterson, BS
影响因子：
6.6
作者：
McCraw, Stacey;Parker, Gordon;Mitchell, P. B.
通讯作者：
Mitchell, P. B.
在未经药物的躁郁症抑郁症，正肌和躁狂症中面部情绪加工过程中的神经激活。
影响因子：
10.6
作者：
Hulvershorn, Leslie A.;Karne, Harish;Gunn, Abigail D.;Hartwick, Sarah L.;Wang, Yang;Hummer, Tom A.;Anand, Amit
通讯作者：
Anand, Amit
影响因子：
6.7
作者：
Drancourt, N.;Etain, B.;Bellivier, F.
通讯作者：
Bellivier, F.