Patterns of Body Composition Relating to Chronic Respiratory Diseases Among Adults in Four Resource-Poor Settings in Peru.

Patterns of Body Composition Relating to Chronic Respiratory Diseases Among Adults in Four Resource-Poor Settings in Peru.
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DOI:
10.1007/s00408-018-0109-7
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发表时间:
2018-06
期刊:
影响因子:
5
通讯作者:
CRONICAS Cohort Study
CRONICAS Cohort Study
中科院分区:
医学3区
文献类型:
--
作者:
Trompeter G;Grigsby MR;Miele CH;Wise RA;Gilman RH;Miranda JJ;Bernabe-Ortiz A;Checkley W;CRONICAS Cohort Study

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已知身体成分会影响慢性呼吸系统疾病(CRDs)的发生和进展。我们试图在秘鲁四种不同的环境中描述哮喘、慢性阻塞性肺疾病(COPD)和慢性支气管炎的独特人体测量表型。我们收集了来自利马、汤贝斯、普诺农村和城市的2959名参与者的社会人口学、临床病史和肺活量测定数据。我们比较了不同研究地点的CRDs患病率,并描述了疾病表型。我们使用单变量和多变量线性回归来模拟CRD状态对身体成分各种描述符的影响。crd的总体患病率因地区而异,利马的哮喘患病率最高(14.5%),普诺农村的COPD患病率最高(9.9%)。不同地点的身体组成测量也各不相同,利马的平均体重指数(BMI)最高(28.4 kg/m2),普诺农村的平均BMI最低(25.2 kg/m2)。COPD患者的平均脂肪质量指数(10.5 kg/m2)和腰围(88.3 cm)最低,而哮喘患者的平均脂肪质量指数(14.5 kg/m2)和腰围(94.8 cm)最高。在多变量分析中,与非慢性阻塞性肺病患者相比,COPD患者的腰围较低(调整后平均为- 2.97 cm, 95%CI为- 4.62至- 1.32)。我们的研究结果提供了证据,表明哮喘和慢性支气管炎更可能与肥胖和高脂肪量相关,而慢性阻塞性肺病与体重不足和瘦质量较少有关。
Body composition is known to influence the development and progression of chronic respiratory diseases (CRDs). We sought to characterize the unique anthropometric phenotypes that present with asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis across four distinct settings in Peru. We collected sociodemographic, clinical history, and spirometry data from 2,959 participants from Lima, Tumbes, and rural and urban Puno. We compared the prevalence of CRDs among different study sites and described disease phenotypes. We used single and multivariable linear regression to model the influence of CRD status on various descriptors of body composition. Overall prevalence of CRDs varied across sites with the highest prevalence of asthma in Lima (14.5%) and the highest prevalence of COPD in rural Puno (9.9%). Measures of body composition also varied across sites, with highest mean body mass index (BMI) in Lima (28.4 kg/m2) and the lowest mean BMI in rural Puno (25.2 kg/m2). Participants with COPD had the lowest mean fat mass index (10.5 kg/m2) and waist circumference (88.3 cm), whereas participants with asthma had the highest mean fat mass index (14.5 kg/m2), and waist circumference (94.8 cm). In multivariable analysis, participants with COPD had a lower waist circumference (adjusted mean −2.97 cm, 95%CI −4.62 to −1.32) when compared to non-CRD participants. Our findings provide evidence that asthma and chronic bronchitis are more likely to be associated with obesity and higher fat mass, while COPD is associated with being underweight and having less lean mass.
3-95 岁年龄范围的多种族肺活量测定参考值:2012 年全球肺功能方程。
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DOI: 10.1186/1476-069x-13-21
发表时间: 2014-03-24
期刊: Environmental health : a global access science source
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通讯作者: CRONICAS Cohort Study Group