Inadvertent relaxation of the ductus arteriosus by pharmacologic agents that are commonly used in the neonatal period.
Inadvertent relaxation of the ductus arteriosus by pharmacologic agents that are commonly used in the neonatal period.
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DOI：
10.1053/j.semperi.2010.02.007
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发表时间：
2010-06
影响因子：
3.4
通讯作者：
Cotton RB
中科院分区：
文献类型：
--
作者：
Reese J;Veldman A;Shah L;Vucovich M;Cotton RB
Premature birth and disruption of the normal maturation process leave the immature ductus arteriosus unable to respond to postnatal cues for closure. Recent strategies that advocate conservative management of the patent ductus arteriosus (PDA) in premature infants are dependent on identification of the symptomatic PDA and understanding the risk factors that predispose to PDA. Exposure of premature infants to unintended vasodilatory stimuli may be one of the risk factors for PDA that is under-recognized. In this paper, we summarize the clinical factors that are associated with PDA and review commonly used neonatal drugs for their vasodilatory properties. Data demonstrating relaxation of the ductus arteriosus by gentamicin and other aminoglycoside antibiotics, by cimetidine and other H2 receptor antagonists, and by heparin are provided as examples of neonatal therapies that have unanticipated effects that may promote PDA.
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影响因子：
3.6
作者：
Clyman, Ronald I.;Roman, Christine
通讯作者：
Roman, Christine
影响因子：
6.3
作者：
DOYLE, PE;BERAL, V;WALE, CJ
通讯作者：
WALE, CJ
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作者：
Botto, LD;Correa, A;Erickson, JD
通讯作者：
Erickson, JD
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ALZAMORACASTRO, V;BATTILANA, G;SIALER, S
通讯作者：
SIALER, S
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158.5
作者：
FRIEDMAN, WF;HIRSCHKLAU, MJ;KIRKPATRICK, SE
通讯作者：
KIRKPATRICK, SE