Dioxin and endometrial progesterone resistance.
Dioxin and endometrial progesterone resistance.
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DOI：
10.1055/s-0029-1242995
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发表时间：
2010-01
影响因子：
2.7
通讯作者：
Osteen KG
中科院分区：
文献类型：
--
作者：
Bruner-Tran KL;Ding T;Osteen KG
子宫内膜异位症的发生可能需要涉及内分泌和免疫系统的多种相互作用的机制。环境毒物，如 2,3,7,8-四氯二苯并-对二恶英 (TCDD)，作为这种疾病发展的潜在促成因素而受到特别关注，因为它们可以破坏这两个系统。然而，要确定环境暴露于 TCDD 在子宫内膜异位症发展中所起的潜在作用，需要更好地了解这种毒物如何影响促进该疾病的生物过程。尽管导致子宫内膜异位症患者子宫内膜孕酮抵抗的疾病机制仍处于推测状态，但我们的研究表明，发育过程中暴露于 TCDD 的小鼠会导致成年动物出现孕酮抵抗表型，这种表型可以持续几代。这些研究和其他研究强调了更好地了解 TCDD 与子宫内膜异位症等生殖疾病相关的作用机制的重要性。
Development of endometriosis likely requires multiple, interactive mechanisms involving both the endocrine and immune systems. Environmental toxicants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are of particular interest as potential contributory agents in the development of this disease because they can disrupt both systems. Nevertheless, defining the potential role that environmental exposure to TCDD plays in the development of endometriosis requires a better understanding of how this toxicant affects the biological processes that promote the disease. Although the disease mechanism(s) responsible for progesterone resistance in the endometrium of endometriosis patients remains speculative, our studies indicate that developmental exposure of mice to TCDD leads to a progesterone-resistant phenotype in adult animals that can persist for several generations. These studies and others underscore the importance of developing a greater understanding of the mechanisms of TCDD action that relate to reproductive disorders such as endometriosis.
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影响因子：
--
作者：
Cunha, GR;Cooke, PS;Kurita, T
通讯作者：
Kurita, T
影响因子：
8.8
作者：
Focant, JF;Pirard, C;De Pauw, E
通讯作者：
De Pauw, E
影响因子：
3.8
作者：
Cummings, AM;Metcalf, JL;Birnbaum, L
通讯作者：
Birnbaum, L
影响因子：
6.7
作者：
Crain DA;Janssen SJ;Edwards TM;Heindel J;Ho SM;Hunt P;Iguchi T;Juul A;McLachlan JA;Schwartz J;Skakkebaek N;Soto AM;Swan S;Walker C;Woodruff TK;Woodruff TJ;Giudice LC;Guillette LJ Jr
通讯作者：
Guillette LJ Jr
DOI：
10.1073/pnas.92.16.7362
发表时间：
1995-08-01
影响因子：
11.1
作者：
BRUNER, KL;RODGERS, WH;OSTEEN, KG
通讯作者：
OSTEEN, KG