Association between Epstein-Barr virus serological reactivation and psychological distress: a cross-sectional study of Japanese community-dwelling older adults.
Association between Epstein-Barr virus serological reactivation and psychological distress: a cross-sectional study of Japanese community-dwelling older adults.
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DOI：
10.18632/aging.204345
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发表时间：
2022-10-21
期刊：
影响因子：
5.2
通讯作者：
Maeda, Takahiro
中科院分区：
文献类型：
--
作者：
Yamanashi, Hirotomo;Akabame, Shogo;Miyata, Jun;Honda, Yukiko;Nonaka, Fumiaki;Shimizu, Yuji;Nakamichi, Seiko;Kawashiri, Shin-Ya;Tamai, Mami;Arima, Kazuhiko;Kawakami, Atsushi;Aoyagi, Kiyoshi;Maeda, Takahiro
EB病毒（EBV）的再活化与多种疾病的发病机制有关。本研究旨在探讨社区老年人心理困扰与EB病毒血清学再激活之间的关系，并评估性别差异在这种关系中的作用。这项基于人群的横断面调查是在接受年度健康检查的个体中进行的（N = 2，821;中位年龄72.4岁）。EBV血清学再激活定义为EBV早期抗原免疫球蛋白G滴度升高，心理困扰定义为Kessler 6评分≥5。采用多变量Logistic回归分析计算EBV血清学再激活和心理困扰的比值比（OR）和95%可信区间（CI）。分别在16.4%和8.7%的参与者中检测到EBV血清学再激活和心理困扰。女性占EBV血清学再激活患者的71%（328/463）。多因素Logistic回归分析显示，所有受试者中心理困扰与EBV血清学再激活无显著相关性（OR 1.31，95% CI：0.95，1.82; P = 0.102）。性别分层的多变量分析显示女性中存在正相关性（OR 1.45，95%CI：1.01，2.08; P = 0.043），但男性中无相关性。EB病毒血清学再激活与社区老年妇女的心理困扰独立相关。我们的研究结果中的性别差异需要进一步研究，以澄清相关的生理机制。
Reactivation of Epstein-Barr virus (EBV) is associated with the etiopathogenesis of a broad spectrum of diseases. This study aimed to investigate the association between psychological distress and EBV serological reactivation among community-dwelling older people and assess the role of sex differences in this association. This population-based cross-sectional survey was conducted among individuals who underwent annual health checkups (N = 2,821; median age 72.4 years). EBV serological reactivation was defined as elevation of EBV early antigen immunoglobulin G titers, and psychological distress was defined as Kessler 6 scores ≥5. Multivariable logistic regression analysis was performed to calculate odds ratios (OR) and 95% confidence intervals (CI) for EBV serological reactivation and psychological distress. EBV serological reactivation and psychological distress were detected in 16.4% and 8.7% of participants, respectively. Women accounted for 71% (328/463) of those with EBV serological reactivation. Multivariable logistic regression analysis showed psychological distress was not significantly associated with EBV serological reactivation among all participants (OR 1.31, 95% CI: 0.95, 1.82; P = 0.102). A sex-stratified multivariable analysis showed a positive association among women (OR 1.45, 95% CI: 1.01, 2.08; P = 0.043), but no association among men. EBV serological reactivation was independently associated with psychological distress in community-dwelling older women. The sex difference in our results warrants further investigation to clarify the physiological mechanisms underlying the association.
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影响因子：
3.1
作者：
GLASER, R;KIECOLTGLASER, JK;HOLLIDAY, JE
通讯作者：
HOLLIDAY, JE
影响因子：
5.2
作者：
Fujiwara S;Nakamura H
通讯作者：
Nakamura H
DOI：
10.5501/wjv.v1.i1.31
发表时间：
2012-02-12
期刊：
World journal of virology
影响因子：
--
作者：
De Paschale, Massimo;Clerici, Pierangelo
通讯作者：
Clerici, Pierangelo
影响因子：
7.2
作者：
Haeri, Sina;Johnson, Nell;Boggess, Kim A.
通讯作者：
Boggess, Kim A.
影响因子：
7.3
作者：
Houen G;Trier NH
通讯作者：
Trier NH