The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus.
The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus.
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循环滤泡 T 辅助细胞与滤泡 T 调节细胞的比率与系统性红斑狼疮的疾病活动度相关
DOI：
10.1016/j.clim.2017.07.004
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Yang N
中科院分区：
文献类型：
--
作者：
Xu B;Wang S;Zhou M;Huang Y;Fu R;Guo C;Chen J;Zhao J;Gaskin F;Fu SM;Yang N
滤泡T调节（Tfr）细胞抑制滤泡T辅助（Tfh）细胞介导的B细胞应答。Tfh细胞参与系统性红斑狼疮（SLE）的发病机制。然而，Tfr细胞在SLE中的作用仍不清楚。在SLE患者和健康对照组中检查循环Tfr和Tfh细胞的频率。SLE患者外周血Tfr细胞频率降低，Tfh/Tfr比值升高。血清抗dsDNA抗体水平与Tfh细胞频率和Tfh/Tfr比值正相关，而与Tfr细胞频率负相关。Tfr频率和Tfh/Tfr比值与疾病活动性相关，而Tfh频率与疾病活动性无关。此外，在成功的治疗中观察到Tfr细胞数量的增加和Tfh/Tfr比率的降低。因此，Tfr细胞应被视为SLE的生物标志物，其在SLE发病机制中的作用值得进一步研究。
Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE remains unclear. The frequency of circulating Tfr and Tfh cells were examined in SLE patients and healthy controls. The frequency of circulating Tfr cell decreased and Tfh/Tfr ratio increased in SLE patients. Serum anti-dsDNA antibody level positively correlated with frequency of Tfh cells and Tfh/Tfr ratios but negatively correlated with the frequency of Tfr cells. Moreover, the frequency of Tfr and Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity. In addition, increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments. Thus, Tfr cells should be considered as a biomarker for SLE and their role in the pathogenesis of SLE warrants further investigation.
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DOI：
10.1038/nrrheum.2012.58
发表时间：
2012-05-01
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1007/978-1-4939-2498-1_17
发表时间：
2015-01-01
期刊：
T FOLLICULAR HELPER CELLS: METHODS AND PROTOCOLS
影响因子：
--
作者：
Wei, Yunbo;Feng, Jinhong;Yu, Di
通讯作者：
Yu, Di
系统性红斑狼疮循环滤泡辅助性T细胞中Bcl-6的表达与疾病活动度呈正相关
影响因子：
8.6
作者：
Huang, Xin;Wu, Haijing;Lu, Qianjin
通讯作者：
Lu, Qianjin
影响因子：
30.5
作者：
Sage PT;Ron-Harel N;Juneja VR;Sen DR;Maleri S;Sungnak W;Kuchroo VK;Haining WN;Chevrier N;Haigis M;Sharpe AH
通讯作者：
Sharpe AH
影响因子：
32.4
作者：
He, Jing;Tsai, Louis M.;Yu, Di
通讯作者：
Yu, Di