A Narrative Review of u-HA/PLLA, a Bioactive Resorbable Reconstruction Material: Applications in Oral and Maxillofacial Surgery.
A Narrative Review of u-HA/PLLA, a Bioactive Resorbable Reconstruction Material: Applications in Oral and Maxillofacial Surgery.
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DOI：
10.3390/ma15010150
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发表时间：
2021-12-26
期刊：
影响因子：
--
通讯作者：
Kanno T
中科院分区：
文献类型：
--
作者：
Ngo HX;Bai Y;Sha J;Ishizuka S;Toda E;Osako R;Kato A;Morioka R;Ramanathan M;Tatsumi H;Okui T;Kanno T
生物可吸收材料的出现克服了其局限性，取代了传统的骨重建钛板系统用于骨固定，从而在医疗和牙科应用中实现了更高的效率和安全性，开启了生物材料发展的新纪元。由于其生物活性的骨传导能力和生物相容性，未焙烧/未烧结的羟基磷灰石/聚L-乳酸锻造复合材料(u-HA/PLLA)引起了骨组织工程研究人员和临床医生的极大兴趣，特别是在颌面重建外科中的应用。因此，各种体外研究、体内研究和临床试验都被用来研究这种生物材料在口腔颌面外科中的可行性和弱点。人们提出了各种技术改进，以优化其优势，限制其劣势。本文就u-HA/PLLA在口腔颌面外科，特别是颌面部创伤、正颌外科和颌面重建中的最新研究进展作一综述。同时介绍了可用于该领域的生物可吸收材料的发展新趋势。各种研究表明，u-HA/PLLA是第三代生物可吸收材料，具有高机械强度、生物相容性和生物活性的骨传导性，与其他生物可吸收材料相比具有优越性。未来的发展可能集中在控制其生物活性和生物降解率，以及提高其机械强度。
The advent of bioresorbable materials to overcome limitations and replace traditional bone-reconstruction titanium-plate systems for bone fixation, thus achieving greater efficiency and safety in medical and dental applications, has ushered in a new era in biomaterial development. Because of its bioactive osteoconductive ability and biocompatibility, the forged composite of uncalcined/unsintered hydroxyapatite and poly L-lactic acid (u-HA/PLLA) has attracted considerable interest from researchers in bone tissue engineering, as well as from clinicians, particularly for applications in maxillofacial reconstructive surgery. Thus, various in vitro studies, in vivo studies, and clinical trials have been conducted to investigate the feasibility and weaknesses of this biomaterial in oral and maxillofacial surgery. Various technical improvements have been proposed to optimize its advantages and limit its disadvantages. This narrative review presents an up-to-date, comprehensive review of u-HA/PLLA, a bioactive osteoconductive and bioresorbable bone-reconstruction and -fixation material, in the context of oral and maxillofacial surgery, notably maxillofacial trauma, orthognathic surgery, and maxillofacial reconstruction. It simultaneously introduces new trends in the development of bioresorbable materials that could used in this field. Various studies have shown the superiority of u-HA/PLLA, a third-generation bioresorbable biomaterial with high mechanical strength, biocompatibility, and bioactive osteoconductivity, compared to other bioresorbable materials. Future developments may focus on controlling its bioactivity and biodegradation rate and enhancing its mechanical strength.
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