Pig models on intestinal development and therapeutics
Pig models on intestinal development and therapeutics
复制标题
猪肠道发育和治疗模型
DOI：
10.1007/s00726-017-2497-z
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发表时间：
2017-10
期刊：
影响因子：
3.5
通讯作者：
Yulong Yin
中科院分区：
文献类型：
--
作者：
Lanmei Yin;Huansheng Yang;Jianzhong Li;Yali Li;Xueqing Ding;Guoyao Wu;Yulong Yin
胃肠道在营养供应、消化和吸收中起着至关重要的作用，对整个机体有着至关重要的影响。利用动物模型研究肠道发育和健康对胃肠道疾病发病机制的影响已受到广泛关注。小猪的体型与人类相似，是一种杂食性动物，具有相似的解剖结构、营养需求以及消化和相关的炎症过程，并显示出与人类肠道微生物生态系统的相似性，这使得小猪比其他非灵长类动物更适合作为人类的动物模型。本文综述了仔猪模型的主要特点，并通过对几种胃肠道疾病的病因学研究，总结了仔猪模型在人类肠道发育和肠道健康研究中的应用，为哺乳动物的营养、健康、疾病和治疗学的进一步研究提供了理论和实践基础。鉴于仔猪和人类之间的营养需求相当，大脑发育模式惊人相似，仔猪已被用作研究儿科营养影响神经发育结果的重要转化模型。由于猪与人类在解剖学和生理学上的相似性，如何利用仔猪模型进行人体器官移植研究越来越受到重视。
The gastrointestinal tract plays a vital role in nutrient supply, digestion, and absorption, and has a crucial impact on the entire organism. Much attention is being paid to utilize animal models to study the pathogenesis of gastrointestinal diseases in response to intestinal development and health. The piglet has a body size similar to that of the human and is an omnivorous animal with comparable anatomy, nutritional requirements, and digestive and associated inflammatory processes, and displays similarities to the human intestinal microbial ecosystem, which make piglets more appropriate as an animal model for human than other non-primate animals. Therefore, the objective of this review is to summarize key attributes of the piglet model with which to study human intestinal development and intestinal health through probing into the etiology of several gastrointestinal diseases, thus providing a theoretical and hopefully practical, basis for further studies on mammalian nutrition, health, and disease, and therapeutics. Given the comparable nutritional requirements and strikingly similar brain developmental patterns between young piglets and humans, the piglet has been used as an important translational model for studying neurodevelopmental outcomes influenced by pediatric nutrition. Because of similarities in anatomy and physiology between pigs and mankind, more emphasises are put on how to use the piglet model for human organ transplantation research.
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DOI：
--
发表时间：
2009-10
期刊：
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
影响因子：
--
作者：
P. Guilloteau;R. Zabielski;H. Hammon;C. Metges
通讯作者：
P. Guilloteau;R. Zabielski;H. Hammon;C. Metges
影响因子：
7
作者：
Ji Y;Wu Z;Dai Z;Wang X;Li J;Wang B;Wu G
通讯作者：
Wu G
DOI：
10.2741/4047
发表时间：
2012-06-01
期刊：
Frontiers in bioscience (Landmark edition)
影响因子：
--
作者：
Tan B;Li X;Yin Y;Wu Z;Liu C;Tekwe CD;Wu G
通讯作者：
Wu G
影响因子：
3.3
作者：
Sangild PT;Thymann T;Schmidt M;Stoll B;Burrin DG;Buddington RK
通讯作者：
Buddington RK
DOI：
10.1007/978-3-7091-1328-8_3
发表时间：
2013
期刊：
--
影响因子：
--
作者：
Huansheng Yang;X. Xiong;Yulong Yin
通讯作者：
Huansheng Yang;X. Xiong;Yulong Yin