Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis.
Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis.
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记忆和焦虑的触觉调节需要沿着背腹轴的齿状颗粒细胞。
DOI：
10.1038/s41467-020-19874-8
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发表时间：
2020-11-27
影响因子：
16.6
通讯作者：
Wang XD
中科院分区：
文献类型：
--
作者：
Wang C;Liu H;Li K;Wu ZZ;Wu C;Yu JY;Gong Q;Fang P;Wang XX;Duan SM;Wang H;Gu Y;Hu J;Pan BX;Schmidt MV;Liu YJ;Wang XD
触摸可以积极影响认知和情绪，但其潜在机制仍不清楚。在这里，我们报告说，触觉经验丰富，改善记忆和减轻焦虑，重塑神经元沿着背腹轴的齿状回（DG）在成年小鼠。触觉富集诱导背侧和腹侧DG神经元的差异激活和结构修饰，并增加与初级体感皮层（S1）相连的外侧内嗅皮层（LEC）向触觉经验激活的DG神经元的突触前输入。触觉经验标记的背侧和腹侧DG神经元的化学发生激活分别增强记忆和减少焦虑，而这些神经元或S1神经支配的LEC神经元的失活则消除了触觉富集的有益作用。此外，成年触觉丰富减弱了早期生活压力引起的记忆缺陷和焦虑相关的行为。我们的研究结果表明，丰富的触觉经验重新调整的途径，从S1 DG和增强DG神经元的可塑性，以调节认知和情绪。触摸可以积极调节认知表现和情绪反应。在这里，作者证明了丰富的触觉体验通过重塑从初级躯体感觉皮层到齿状回的通路来改善成年小鼠的记忆并减少焦虑。
Touch can positively influence cognition and emotion, but the underlying mechanisms remain unclear. Here, we report that tactile experience enrichment improves memory and alleviates anxiety by remodeling neurons along the dorsoventral axis of the dentate gyrus (DG) in adult mice. Tactile enrichment induces differential activation and structural modification of neurons in the dorsal and ventral DG, and increases the presynaptic input from the lateral entorhinal cortex (LEC), which is reciprocally connected with the primary somatosensory cortex (S1), to tactile experience-activated DG neurons. Chemogenetic activation of tactile experience-tagged dorsal and ventral DG neurons enhances memory and reduces anxiety respectively, whereas inactivation of these neurons or S1-innervated LEC neurons abolishes the beneficial effects of tactile enrichment. Moreover, adulthood tactile enrichment attenuates early-life stress-induced memory deficits and anxiety-related behavior. Our findings demonstrate that enriched tactile experience retunes the pathway from S1 to DG and enhances DG neuronal plasticity to modulate cognition and emotion. Touch can positively modulate cognitive performance and emotional response. Here the authors demonstrate that enriched tactile experience improves memory and reduces anxiety in adult mice by remodelling the pathway from the primary somatosensory cortex to the dentate gyrus.
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DOI：
10.1002/syn.21900
发表时间：
2016-07
期刊：
Synapse (New York, N.Y.)
影响因子：
--
作者：
Gallitano AL;Satvat E;Gil M;Marrone DF
通讯作者：
Marrone DF
我们能否调和关于海马功能的陈述性记忆和空间导航观点？
影响因子：
16.2
作者：
Eichenbaum H;Cohen NJ
通讯作者：
Cohen NJ
影响因子：
5.3
作者：
Baldini, Sara;Restani, Laura;Berardi, Nicoletta
通讯作者：
Berardi, Nicoletta
DOI：
10.1073/pnas.1218991110
发表时间：
2013-03-19
影响因子：
11.1
作者：
Deshpande, Aditi;Bergami, Matteo;Berninger, Benedikt
通讯作者：
Berninger, Benedikt
影响因子：
3.1
作者：
Canto CB;Wouterlood FG;Witter MP
通讯作者：
Witter MP