Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes.
Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes.
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DOI：
10.1016/j.protis.2010.09.001
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发表时间：
2010-12
期刊：
影响因子：
2.5
通讯作者：
Dawson SC
中科院分区：
文献类型：
--
作者：
Ginger ML;Fritz-Laylin LK;Fulton C;Cande WZ;Dawson SC
原生生物占真核生物多样性的大部分。通过研究基因，特别是基因组序列，可以确定这种多样性的分子基础。从基因组测序中可以明显看出，多种代谢的例子远远超出了教科书中描述的真核生物的典型途径。在过去的2-3年中，基因组测序和转录谱分析已经揭示了异养和光养原生生物的几个例子，这些原生生物出乎意料地装备良好，可以使用兼性厌氧代谢生产ATP，包括一些原生生物（莱茵衣藻）或预测（耐格里虫，卡氏阿米巴，寄生变形虫）在其代谢中产生H2。有可能某些厌氧代谢酶是通过横向转移获得并分布在真核生物中的，但也有可能真核生物的共同祖先已经具有比几年前广泛认为的更多的代谢多样性。本文就单细胞真核生物核心能量代谢的研究进展作一综述。由于基因组测序到目前为止只触及原生生物多样性的表面，预计其他原生生物的序列可能会揭示更广泛的代谢能力，同时丰富我们对真核生物早期进化的理解。
Protists account for the bulk of eukaryotic diversity. Through studies of gene and especially genome sequences the molecular basis for this diversity can be determined. Evident from genome sequencing are examples of versatile metabolism that go far beyond the canonical pathways described for eukaryotes in textbooks. In the last 2–3 years, genome sequencing and transcript profiling has unveiled several examples of heterotrophic and phototrophic protists that are unexpectedly well-equipped for ATP production using a facultative anaerobic metabolism, including some protists that can (Chlamydomonas reinhardtii) or are predicted (Naegleria gruberi, Acanthamoeba castellanii, Amoebidium parasiticum) to produce H2 in their metabolism. It is possible that some enzymes of anaerobic metabolism were acquired and distributed among eukaryotes by lateral transfer, but it is also likely that the common ancestor of eukaryotes already had far more metabolic versatility than was widely thought a few years ago. The discussion of core energy metabolism in unicellular eukaryotes is the subject of this review. Since genomic sequencing has so far only touched the surface of protist diversity, it is anticipated that sequences of additional protists may reveal an even wider range of metabolic capabilities, while simultaneously enriching our understanding of the early evolution of eukaryotes.
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影响因子：
3.3
作者：
Cavalier-Smith, Thomas
通讯作者：
Cavalier-Smith, Thomas
影响因子：
56.9
作者：
Armbrust, EV;Berges, JA;Rokhsar, DS
通讯作者：
Rokhsar, DS
影响因子：
64.8
作者：
Boxma, B;de Graaf, RM;Hackstein, JHP
通讯作者：
Hackstein, JHP
影响因子：
2.5
作者：
Cavalier-Smith, Thomas;Chao, Ema E.
通讯作者：
Chao, Ema E.
DOI：
10.1111/j.1432-1033.1996.0155t.x
发表时间：
1996-10-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Brown, DM;Upcroft, JA;Upcroft, P
通讯作者：
Upcroft, P