Population-based genomic study of Plasmodium vivax malaria in seven Brazilian states and across South America.
Population-based genomic study of Plasmodium vivax malaria in seven Brazilian states and across South America.
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DOI：
10.1016/j.lana.2022.100420
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发表时间：
2023-03
期刊：
影响因子：
--
通讯作者：
Campino, Susana
中科院分区：
文献类型：
--
作者：
Ibrahim, Amy;Manko, Emilia;Dombrowski, Jamille G.;Campos, Monica;Benavente, Ernest Diez;Nolder, Debbie;Sutherland, Colin J.;Nosten, Francois;Fernandez, Diana;Velez-Tobon, Gabriel;Castano, Alberto Tobon;Aguiar, Anna Caroline C.;Pereira, Dhelio Batista;Santos, Simone da Silva;Suarez-Mutis, Martha;Di Santi, Silvia Maria;Baptista, Andrea Regina de Souza;Machado, Ricardo Luiz Dantas;Marinho, Claudio R. F.;Clark, Taane G.;Campino, Susana
关键词：
巴西是一个独特的疟疾研究不足的环境，具有与人类和环境条件相关的复杂的传播中心。了解巴西各地间日疟原虫的种群基因组多样性可以支持疟疾控制战略。通过对巴西7个州的间日疟原虫分离株进行全基因组测序，我们使用群体基因组方法比较了国家（n = 123）、大陆（6个国家，n = 315）和全球（26个国家，n = 885）的遗传多样性。我们证实，南美分离株是不同的，有更多的祖先群体比其他全球地区，与抗疟药物（pvmdr 1，pvdhfr-ts）和蚊子载体（pvcrmp 3，pvP 45/48，pvP 47）的选择性压力下的基因分化突变。我们证明巴西作为一个独特的寄生虫种群，选择的信号，包括ABC转运蛋白（PvABCI 3）和PHIST出口蛋白。巴西有一个复杂的人口结构，有证据表明，P. simium感染和亚马逊寄生虫分成多个集群。总的来说，我们的工作提供了第一个巴西范围内的间日疟原虫种群结构分析，并确定了重要的突变，这可以为未来的研究和控制措施提供信息。AI由LiD博士生资助。TGC由基金会资助（资助号：MR/M01360 X/1、MR/N 010469/1、MR/R 025576/1、MR/R 020973/1和MR/X 005895/1）。SC由英国赠款（MR/M01360 X/1、MR/R 025576/1、MR/R 020973/1和MR/X 005895/1）和Bloomsbury SET（参考CCF 17 -7779）资助。FN由Shloklo疟疾研究单位资助，该研究单位是Mahidol牛津研究单位的一部分，由（批准号220211）支持。ARSB的资金来自（第2002/09546-1号赠款）。RLDM由以下机构资助（批准号：302353/2003-8和471605/2011-5）; CRFM的资金来自（批准号：2020/06747-4）和（批准号302917/2019-5和408636/2018-1）; JGD由奖学金（2016/13465-0和2019/12068-5）和（批准号409216/2018-6）资助。
Brazil is a unique and understudied setting for malaria, with complex foci of transmission associated with human and environmental conditions. An understanding of the population genomic diversity of P. vivax parasites across Brazil can support malaria control strategies. Through whole genome sequencing of P. vivax isolates across 7 Brazilian states, we use population genomic approaches to compare genetic diversity within country (n = 123), continent (6 countries, n = 315) and globally (26 countries, n = 885). We confirm that South American isolates are distinct, have more ancestral populations than the other global regions, with differentiating mutations in genes under selective pressure linked to antimalarial drugs (pvmdr1, pvdhfr-ts) and mosquito vectors (pvcrmp3, pvP45/48, pvP47). We demonstrate Brazil as a distinct parasite population, with signals of selection including ABC transporter (PvABCI3) and PHIST exported proteins. Brazil has a complex population structure, with evidence of P. simium infections and Amazonian parasites separating into multiple clusters. Overall, our work provides the first Brazil-wide analysis of P. vivax population structure and identifies important mutations, which can inform future research and control measures. AI is funded by an LiD PhD studentship. TGC is funded by the (Grant no. MR/M01360X/1, MR/N010469/1, MR/R025576/1, MR/R020973/1 and MR/X005895/1). SC is funded by UK grants (MR/M01360X/1, MR/R025576/1, MR/R020973/1 and MR/X005895/1) and Bloomsbury SET (ref. CCF17-7779). FN is funded by The Shloklo Malaria Research Unit - part of the Mahidol Oxford Research Unit, supported by the (Grant no. 220211). ARSB is funded by (Grant no. 2002/09546–1). RLDM is funded by (Grant no. 302353/2003–8 and 471605/2011–5); CRFM is funded by (Grant no. 2020/06747–4) and (Grant no. 302917/2019–5 and 408636/2018–1); JGD is funded by fellowships (2016/13465–0 and 2019/12068–5) and (Grant no. 409216/2018–6).
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影响因子：
3.2
作者：
Almeida ACG;Kuehn A;Castro AJM;Vitor-Silva S;Figueiredo EFG;Brasil LW;Brito MAM;Sampaio VS;Bassat Q;Felger I;Tadei WP;Monteiro WM;Mueller I;Lacerda MVG
通讯作者：
Lacerda MVG
影响因子：
13.6
作者：
Daron J;Boissière A;Boundenga L;Ngoubangoye B;Houze S;Arnathau C;Sidobre C;Trape JF;Durand P;Renaud F;Fontaine MC;Prugnolle F;Rougeron V
通讯作者：
Rougeron V
影响因子：
3.7
作者：
Diez Benavente E;Ward Z;Chan W;Mohareb FR;Sutherland CJ;Roper C;Campino S;Clark TG
通讯作者：
Clark TG
影响因子：
3
作者：
Abate, Andargie;Bouyssou, Isabelle;Mabilotte, Solenne;Doderer-Lang, Cecile;Dembele, Laurent;Menard, Didier;Golassa, Lemu
通讯作者：
Golassa, Lemu
影响因子：
1.2
作者：
Cingolani, Pablo;Platts, Adrian;Ruden, Douglas M.
通讯作者：
Ruden, Douglas M.