Serum microRNA-21 levels are related to tumor size in gastric cancer patients but cannot predict prognosis.
Serum microRNA-21 levels are related to tumor size in gastric cancer patients but cannot predict prognosis.
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DOI：
10.3892/ol.2013.1626
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发表时间：
2013-12
期刊：
影响因子：
2.9
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Song J;Bai Z;Zhang J;Meng H;Cai J;Deng W;Bi J;Ma X;Zhang Z
在胃癌 (GC) 患者中，循环 microRNA-21 (miR-21) 过度表达，可作为诊断生物标志物。在本研究中，假设血清miR-21表达水平与GC患者的预后相关。使用定量聚合酶链反应 (qPCR) 测定 103 名 GC 患者的血清 miR-21 表达水平。进行生存和 Cox 比例风险回归分析以确定患者血清 miR-21 表达水平与预后之间的相关性。分析患者血清miR-21水平与临床病理因素的相关性。血清 miR-21 表达水平高和低的组之间的生存曲线没有显着差异。血清中高水平的 miR-21 与肿瘤大小增加和 pT 分期晚期相关。这些发现表明，血清 miR-21 可作为监测 GC 患者肿瘤负荷的实用生物标志物。
In patients with gastric cancer (GC), circulating microRNA-21 (miR-21) is overexpressed and may serve as a diagnostic biomarker. In the present study, it was hypothesized that the serum miR-21 expression levels were associated with prognosis in the patients with GC. The expression levels of serum miR-21 were measured using quantitative polymerase chain reaction (qPCR) assays in 103 GC patients. Survival and Cox proportional-hazards regression analyses were performed to determine the correlation between serum miR-21 expression levels and prognosis in the patients. The correlation between the serum miR-21 levels and the clinicopathological factors of the patients was also analyzed. Survival curves were not significantly different between the groups exhibiting high and low levels of serum miR-21 expression. High levels of miR-21 in the serum were associated with an increased tumor size and an advanced pT stage. These findings suggest that serum miR-21 could be exploited as a practical biomarker for monitoring tumor burden in patients with GC.
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影响因子：
11.2
作者：
Wang P;Zou F;Zhang X;Li H;Dulak A;Tomko RJ Jr;Lazo JS;Wang Z;Zhang L;Yu J
通讯作者：
Yu J
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
3.4
作者：
Le, Han-Bo;Zhu, Wang-Yu;Zhang, Yong-Kui
通讯作者：
Zhang, Yong-Kui
DOI：
10.1016/j.bbrc.2009.03.077
发表时间：
2009-06-05
影响因子：
3.1
作者：
Li, Tao;Li, Dong;Huang, Yiran
通讯作者：
Huang, Yiran
影响因子：
6.5
作者：
Lawrie, Charles H.;Gal, Shira;Harris, Adrian L.
通讯作者：
Harris, Adrian L.