Roles of the HOX Proteins in Cancer Invasion and Metastasis.
Roles of the HOX Proteins in Cancer Invasion and Metastasis.
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DOI：
10.3390/cancers13010010
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发表时间：
2020-12-22
期刊：
影响因子：
5.2
通讯作者：
Freitas R
中科院分区：
文献类型：
--
作者：
Paço A;Aparecida de Bessa Garcia S;Leitão Castro J;Costa-Pinto AR;Freitas R
癌症是仅次于心血管疾病的全球第二大死亡原因，并且侵袭和转移对应于癌症相关死亡的首要原因。在这里，我们回顾了HOX转录因子在癌症进展的最后几个步骤中的重要性，并描述了它们的五种复杂的调节机制，包括miR和lncRNA干扰。这些信息强调了HOX在抑制和诱导疾病进展方面的重要性，并指出HOX产品作为不同癌症类型治疗靶点的潜力。侵袭和转移对应于癌症相关死亡的最主要原因，并且这两个过程背后的分子网络极其复杂，并且依赖于细胞内和细胞外条件以及转移前小生境的主要条件（prime）沿着。目前，一些研究表明HOX基因表达水平与癌细胞侵袭和转移之间存在关联，这有利于新肿瘤块的形成。HMGA 2/TET 1信号对HOX基因的失调和HOX基因座产生的非编码RNA的调节作用也可促进侵袭和转移，干扰HOX基因或与这些过程相关的其他基因的表达。在这篇综述中，我们提出了五个HOX失调的分子机制，HOX簇产物可能会影响实体瘤的侵袭和转移过程。
Cancer is the second leading cause of death worldwide, right after cardiovascular diseases, and the invasion and metastatization correspond to the foremost cause of cancer-related deaths. Here, we reviewed the state of the art regarding the importance of HOX transcription factors in these last steps of cancer progression and described five of their complex mechanisms of regulation, including the miRs and lncRNAs interference. This information highlights the importance of HOX in the suppression and induction of disease advancement and point out the potential of HOX products as therapeutic targets for diverse cancer types. Invasion and metastasis correspond to the foremost cause of cancer-related death, and the molecular networks behind these two processes are extremely complex and dependent on the intra- and extracellular conditions along with the prime of the premetastatic niche. Currently, several studies suggest an association between the levels of HOX genes expression and cancer cell invasion and metastasis, which favour the formation of novel tumour masses. The deregulation of HOX genes by HMGA2/TET1 signalling and the regulatory effect of noncoding RNAs generated by the HOX loci can also promote invasion and metastasis, interfering with the expression of HOX genes or other genes relevant to these processes. In this review, we present five molecular mechanisms of HOX deregulation by which the HOX clusters products may affect invasion and metastatic processes in solid tumours.
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影响因子：
3.9
作者：
Costanza B;Umelo IA;Bellier J;Castronovo V;Turtoi A
通讯作者：
Turtoi A
影响因子：
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