Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Event-Related Potential (ERP) Indices of Attention in Autism.
Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Event-Related Potential (ERP) Indices of Attention in Autism.
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DOI：
10.2478/s13380-012-0022-0
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发表时间：
2012-06-01
影响因子：
2.1
通讯作者：
Sokhadze E
中科院分区：
文献类型：
--
作者：
Casanova MF;Baruth JM;El-Baz A;Tasman A;Sears L;Sokhadze E
患有自闭症谱系障碍（ASD）的个体先前已被证明与早期和后期阶段的对照相比，对不相关的视觉刺激具有显著增强和延长的事件相关电位（ERP）（例如，N200，P300）的视觉处理和证据的整体缺乏刺激的歧视。对感觉刺激的异常大和不加区分的皮层反应可能反映了皮层抑制缺陷和兴奋/抑制比的破坏。低频（≤1HZ）重复经颅磁刺激（rTMS）已被证明可以通过激活抑制回路来增加受刺激皮层的抑制。我们预测，在ASD患者的背外侧前额叶皮质双侧应用12次低频rTMS后，在稍后（即，200-600 ms）阶段的注意力处理以及运动反应错误率的改善。我们评估了25名参与者与ASD的选择性注意力的任务，使用虚幻的数字之前和之后的12个会议的rTMS在一个控制的设计，其中一个等待名单组的20名ASD儿童进行了相同的任务两次。我们发现，作为rTMS的结果，N200和P300组件的显着改善，以及显着减少响应错误。我们还发现，作为rTMS的结果，根据临床行为问卷，重复行为和易怒都显着减少。我们认为rTMS有可能成为ASD研究和治疗的重要治疗工具。
Individuals with autism spectrum disorder (ASD) have previously been shown to have significantly augmented and prolonged event-related potentials (ERP) to irrelevant visual stimuli compared to controls at both early and later stages (e.g., N200, P300) of visual processing and evidence of an overall lack of stimulus discrimination. Abnormally large and indiscriminative cortical responses to sensory stimuli may reflect cortical inhibitory deficits and a disruption in the excitation/inhibition ratio. Low-frequency (≤1HZ) repetitive transcranial magnetic stimulation (rTMS) has been shown to increase inhibition of stimulated cortex by the activation of inhibitory circuits. It was our prediction that after 12 sessions of low-frequency rTMS applied bilaterally to the dorsolateral prefrontal cortices in individuals with ASD there would be a significant improvement in ERP indices of selective attention evoked at later (i.e., 200–600 ms) stages of attentional processing as well as an improvement in motor response error rate. We assessed 25 participants with ASD in a task of selective attention using illusory figures before and after 12 sessions of rTMS in a controlled design where a waiting-list group of 20 children with ASD performed the same task twice. We found a significant improvement in both N200 and P300 components as a result of rTMS as well as a significant reduction in response errors. We also found significant reductions in both repetitive behavior and irritability according to clinical behavioral questionnaires as a result of rTMS. We propose that rTMS has the potential to become an important therapeutic tool in ASD research and treatment.
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影响因子：
1.9
作者：
Casanova, MF;Buxhoeveden, DP;Brown, C
通讯作者：
Brown, C
DOI：
10.1176/appi.neuropsych.14.4.406
发表时间：
2002-09-01
影响因子：
2.9
作者：
Daskalakis, ZJ;Christensen, BK;Chen, R
通讯作者：
Chen, R
影响因子：
2.5
作者：
Donkers, FCL;van Boxtel, GJM
通讯作者：
van Boxtel, GJM
DOI：
10.1016/s0926-6410(03)00189-7
发表时间：
2003-10-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Belmonte, MK;Yurgelun-Todd, DA
通讯作者：
Yurgelun-Todd, DA
影响因子：
1.9
作者：
Casanova, MF;Buxhoeveden, DP;Roy, E
通讯作者：
Roy, E