The basolateral amygdala to posterior insular cortex tract is necessary for social interaction with stressed juvenile rats.
The basolateral amygdala to posterior insular cortex tract is necessary for social interaction with stressed juvenile rats.
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DOI：
10.1016/j.bbr.2022.114050
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发表时间：
2022-10-28
影响因子：
2.7
通讯作者：
Christianson, John P.
中科院分区：
文献类型：
--
作者：
Djerdjaj, Anthony;Ng, Alexandra J.;Rieger, Nathaniel S.;Christianson, John P.
发声、化学信号和行为受到一个人的内部情感状态的影响，并被其他人用来塑造社会行为。一个相互连接的大脑结构网络，通常被称为社会行为网络或社会决策网络，整合这些刺激并协调社会行为，网络内连接缺陷是精神分裂症和自闭症谱系障碍等精神疾病的基础。在这里，我们调查的作用，基底外侧杏仁核（BLA）和它的预测后岛叶皮层，独立地牵连在一系列的社会认知过程中，在社会情感偏好（SAP）测试。将含有编码抑制性化学发生受体的基因的病毒载体（AAV 5-hSyn-hM 4Di-mCherry）注射到BLA中。在通过全身施用hM 4Di激动剂氯氮平-n-氧化物（CNO）抑制BLA或通过将CNO直接输注至丘脑抑制BLA-c末端后，进行SAP测试，其允许观察对他人情感状态的无条件行为反应。溶媒输注后，大鼠表现出与应激幼年同种动物相互作用的偏好。然而，CNO治疗消除了偏好行为。目前的研究结果表明，社会决策涉及的情绪信息从BLA的转移到的BLA，这是一个以前未被认识的社会认知的解剖基板。
Vocalizations, chemosignals, and behaviors are influenced by one’s internal affective state and are used by others to shape social behaviors. A network of interconnected brain structures, often called the social behavior network or social decision-making network, integrates these stimuli and coordinates social behaviors, and in-network connectivity deficits underlie several psychiatric disorders such as schizophrenia and autism spectrum disorders. Here, we investigated the role of the basolateral amygdala (BLA) and its projections to the posterior insular cortex, regions independently implicated in a range of sociocognitive processes, in a social affective preference (SAP) test. Viral vectors containing the gene coding for inhibitory chemogenetic receptors (AAV5-hSyn-hM4Di-mCherry) were injected into the BLA. SAP tests, which allow for the observation of unconditioned behavioral responses to the affective states of others, were conducted after inhibition of the BLA by systemic administration of the hM4Di agonist clozapine-n-oxide (CNO), or inhibition of BLA-insula terminals by direct infusion of CNO to the insula. After vehicle infusions, rats displayed preference for interactions with stressed juvenile conspecifics. However, CNO treatment eliminated preference behavior. The current results suggest that social decision making involves the transfer of emotional information from the BLA to the insula which represents a previously unrecognized anatomical substrate for social cognition.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
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作者：
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Maier, Steven F.
影响因子：
9.2
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Ramirez, Steve
影响因子：
5.7
作者：
Baas, Daan;Aleman, Andre;Kahn, Rene S.
通讯作者：
Kahn, Rene S.
影响因子：
64.5
作者：
Gore F;Schwartz EC;Brangers BC;Aladi S;Stujenske JM;Likhtik E;Russo MJ;Gordon JA;Salzman CD;Axel R
通讯作者：
Axel R