Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee.

Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee.
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DOI:
10.1055/s-0043-1775741
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发表时间:
2023-12
影响因子:
1.4
通讯作者:
--
中科院分区:
医学4区
文献类型:
--
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慢性膝关节疼痛是一种常见的疾病。膝关节疼痛的原因包括创伤、炎症和退行性变,但在许多患者中,病理生理学仍然未知。先进的磁共振成像(MRI)技术和分子成像的最新发展促进了更深入的研究,重点是慢性肌肉骨骼疼痛的病理生理学,更具体地说是炎症。即将到来的新见解可以帮助开发更好的靶向治疗,一些成像技术甚至可以作为未来预测和评估治疗反应的成像生物标志物。本文综述了灌注MRI、扩散MRI和正电子发射断层扫描/MRI分子成像的最新进展及其在膝关节疼痛中的应用。主要的焦点是滑膜炎症,也称为滑膜炎。骨灌注和骨代谢也得到解决。
Chronic knee pain is a common condition. Causes of knee pain include trauma, inflammation, and degeneration, but in many patients the pathophysiology remains unknown. Recent developments in advanced magnetic resonance imaging (MRI) techniques and molecular imaging facilitate more in-depth research focused on the pathophysiology of chronic musculoskeletal pain and more specifically inflammation. The forthcoming new insights can help develop better targeted treatment, and some imaging techniques may even serve as imaging biomarkers for predicting and assessing treatment response in the future. This review highlights the latest developments in perfusion MRI, diffusion MRI, and molecular imaging with positron emission tomography/MRI and their application in the painful knee. The primary focus is synovial inflammation, also known as synovitis. Bone perfusion and bone metabolism are also addressed.
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