Diffusion-weighted imaging for assessment of synovial inflammation in juvenile idiopathic arthritis: a promising imaging biomarker as an alternative to gadolinium-based contrast agents.
Diffusion-weighted imaging for assessment of synovial inflammation in juvenile idiopathic arthritis: a promising imaging biomarker as an alternative to gadolinium-based contrast agents.
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DOI：
10.1007/s00330-017-4876-y
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发表时间：
2017-11
影响因子：
5.9
通讯作者：
Maas M
中科院分区：
文献类型：
--
作者：
Barendregt AM;van Gulik EC;Lavini C;Nusman CM;van den Berg JM;Schonenberg-Meinema D;Dolman KM;Kuijpers TW;Hemke R;Maas M
比较动态增强MRI （DCE）和弥散加权成像（DWI）对幼年特发性关节炎（JIA）滑膜炎症的定量诊断。在JIA患者的T1 DCE和T2 DWI滑膜上绘制感兴趣区域（ROI），提取最大增强（ME）、最大初始斜率（MIS）、峰值时间（TTP）、不同时间强度曲线形状百分比（TIC）和表观扩散系数（ADC）。采用Mann-Whitney-U检验比较MRI活跃和非活跃患者（由青少年关节炎MRI评分系统定义）的参数。采用Spearman秩分析DCE与DWI的相关性。纳入35例JIA患者（MRI活跃18例，MRI不活跃17例）。中位年龄为13.1岁，71%为女性。mri活性JIA与mri非活性JIA的ME、MIS、TTP、% TIC 5和ADC差异有统计学意义，mri活性JIA的中位数ADC为1.49 × 10-3mm2/s， mri非活性JIA的中位数ADC为1.25 × 10-3mm2/s, p = 0.001，中位数差异的95%置信区间为0.11 ~ 0.53 × 10-3mm2/s。ADC与ME、MIS、TIC 5形态相关（r = 0.62、r = 0.45、r = -0.51，均p < 0.05）。与DCE参数类似，dwi衍生的ADC在mri活性JIA中与mri非活性JIA中有显著差异。DWI的无创性及其检测滑膜炎症的可能性显示了DWI的潜力。•MRI可以量化：动态对比增强和弥散加权MRI可以量化滑膜炎•DWI和DCE都可以区分活动性和非活动性JIA•DWI衍生的表观扩散系数（ADC）在活动性JIA中更高•DWI是非侵入性的，因此更安全，对患者更友好•DWI是潜在强大的非侵入性JIA成像生物标志物
To compare dynamic-contrast-enhanced MRI (DCE) and diffusion-weighted imaging (DWI) in quantifying synovial inflammation in juvenile idiopathic arthritis (JIA). Regions of interest (ROI) were drawn in the synovium of JIA patients on T1 DCE and T2 DWI, followed by extraction of the maximum enhancement (ME), maximum initial slope (MIS), time to peak (TTP), % of different time intensity curve shapes (TIC) and apparent diffusion coefficient (ADC) of the ROIs. Mann-Whitney-U test was used for comparing parameters between MRI-active and -inactive patients (defined by the juvenile arthritis MRI scoring system). Spearman’s rank was used to analyse the correlation between DCE and DWI. Thirty-five JIA patients (18 MRI active and 17 MRI inactive) were included. Median age was 13.1 years and 71% were female. ME, MIS, TTP, % TIC 5 and ADC were significantly different in MRI-active versus MRI-inactive JIA with median ADC 1.49 × 10-3mm2/s in MRI-active and 1.25 × 10-3mm2/s in MRI-inactive JIA, p = 0.001, 95% confidence interval of difference in medians =0.11-0.53 × 10-3mm2/s. ADC correlated to ME, MIS and TIC 5 shapes (r = 0.62, r = 0.45, r = -0.51, respectively, all p < 0.05). Similar to DCE parameters, DWI-derived ADC is significantly different in MRI-active JIA as compared to MRI-inactive JIA. The non-invasiveness of DWI combined with its possibility to detect synovial inflammation shows the potential of DWI. • MRI can quantify: dynamic contrast-enhanced and diffusion-weighted MRI can quantify synovitis • Both DWI and DCE can differentiate active from inactive JIA • The DWI-derived apparent diffusion coefficient (ADC) is higher in active JIA • DWI is non-invasive and thus safer and more patient-friendly • DWI is a potentially powerful and non-invasive imaging biomarker for JIA
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DOI：
10.1016/j.berh.2013.03.006
发表时间：
2013-04-01
影响因子：
5.2
作者：
Gerlag, Danielle M.;Tak, Paul P.
通讯作者：
Tak, Paul P.
影响因子：
5.5
作者：
Malattia, Clara;Damasio, Maria B.;Martini, Alberto
通讯作者：
Martini, Alberto
影响因子：
--
作者：
TAMAI, K;YAMATO, M;OHNO, W
通讯作者：
OHNO, W
影响因子：
3.3
作者：
Bellin, Marie-France;Van Der Molen, Aart J.
通讯作者：
Van Der Molen, Aart J.
影响因子：
5.5
作者：
Gattorno, M;Gregorio, A;Martini, A
通讯作者：
Martini, A