Fronto-medial theta coordinates posterior maintenance of working memory content.
Fronto-medial theta coordinates posterior maintenance of working memory content.
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额 - 内侧theta坐在工作记忆内容的后验维护。
DOI：
10.1016/j.cub.2022.03.045
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发表时间：
2022-05-23
期刊：
影响因子：
9.2
通讯作者：
Staresina, Bernhard P.
中科院分区：
文献类型：
--
作者：
Ratcliffe, Oliver;Shapiro, Kimron;Staresina, Bernhard P.
人类大脑是如何管理多重信息来指导目标导向的行为的？成功的工作记忆（WM）功能一直与额-内侧皮层（额-内侧θ [FMT]）上的θ频段（4-8 Hz）的振荡功率有关。具体来说，FMT被认为反映了一个执行子系统的机制，该子系统协调后脑区记忆内容的维持。然而，关于FMT在控制特定WM含量中的作用的直接证据是缺乏的。在本研究中，我们收集了参与者在从事脑电信号依赖任务时的高密度脑电图（EEG）数据，然后使用多元解码方法来检测维持期脑电信号的内容。WM的参与伴随着FMT的重点增加。重要的是，WM内容的解码是由后脑区驱动的，而后脑区又显示出与额-内侧通道增加的功能性θ波耦合。最后，我们观察到FMT频率随着WM负荷的增加而显著减慢，这与假设的“占空比”的扩大相一致，以适应额外的WM项目。综上所述，这些研究结果表明，额叶θ波协调了WM内容的后侧维持。此外，观察到的频率变慢通过特别支持WM的相位编码说明了FMT振荡的功能。在WM工作期间，FMT功率支持WM功能，后/顶叶区域与FMT相耦合，WM内容的多元解码由这些相同的后通道介导，额叶θ波频率随着WM负载支持相位编码模型而减慢。Ratcliffe等人显示，工作记忆（WM）在额内侧皮层需要增加θ波功率（4-8 Hz）。WM的内容，反过来，可以从显示与额叶皮质功能耦合的后脑区解码。最后，在WM中持有一个额外的项目会显著减缓额叶θ节律，支持WM功能的相位编码解释。
How does the human brain manage multiple bits of information to guide goal-directed behavior? Successful working memory (WM) functioning has consistently been linked to oscillatory power in the theta frequency band (4–8 Hz) over fronto-medial cortex (fronto-medial theta [FMT]). Specifically, FMT is thought to reflect the mechanism of an executive sub-system that coordinates maintenance of memory contents in posterior regions. However, direct evidence for the role of FMT in controlling specific WM content is lacking. Here, we collected high-density electroencephalography (EEG) data while participants engaged in WM-dependent tasks and then used multivariate decoding methods to examine WM content during the maintenance period. Engagement of WM was accompanied by a focal increase in FMT. Importantly, decoding of WM content was driven by posterior sites, which, in turn, showed increased functional theta coupling with fronto-medial channels. Finally, we observed a significant slowing of FMT frequency with increasing WM load, consistent with the hypothesized broadening of a theta “duty cycle” to accommodate additional WM items. Together, these findings demonstrate that frontal theta orchestrates posterior maintenance of WM content. Moreover, the observed frequency slowing elucidates the function of FMT oscillations by specifically supporting phase-coding accounts of WM. FMT power supports WM functions During WM performance, posterior/parietal regions are coupled with FMT Multivariate decoding of WM content is mediated by these same posterior channels Frontal theta frequency slows with WM load supporting phase-coding models Ratcliffe et al. show working memory (WM) demands increase theta power (4–8 Hz) in fronto-medial cortex. WM content, in turn, is decodable from posterior areas showing functional coupling with frontal cortex. Finally, holding an additional item in WM significantly slows the frontal theta rhythm, supporting phase-coding accounts of WM function.
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DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
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作者：
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