Differential effects of 5-HT(2A) and 5-HT(2C) receptor blockade on strategy-switching.
Differential effects of 5-HT(2A) and 5-HT(2C) receptor blockade on strategy-switching.
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DOI：
10.1016/j.bbr.2010.12.031
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发表时间：
2011-05-16
影响因子：
2.7
通讯作者：
Ragozzino, Michael E.
中科院分区：
文献类型：
--
作者：
Baker, Phillip M.;Thompson, Jennifer L.;Sweeney, John A.;Ragozzino, Michael E.
最近的实验表明，5-羟色胺（5-HT）2A和2C受体的阻断对逆转学习有不同的影响。本实验研究了5-HT_（2A）受体拮抗剂酮色林和5-HT_（2C）受体拮抗剂SB_（242084）对视觉提示-反应范式中策略转换的影响。Long-Evans大鼠在交叉迷宫中接受训练，根据颜色（视觉提示版本）或特定的转弯反应（反应版本）进入手臂。酮色林全身治疗不影响视觉提示或反应辨别的初始学习，但0.5 mg/kg的酮色林显著增强了视觉提示和反应策略之间的切换。酮色林通过抑制对先前相关策略的反应而促进策略转换，而不会影响对从未加强的策略的选择。SB 242084（0.5、1.0或2.0 mg/kg）处理不影响视觉提示或反应辨别的获得。SB 242084治疗也不影响策略转换。目前的研究结果表明，5-HT 2A，而不是5-HT 2C，受体的阻断增强策略转换。
Recent experiments indicate that blockade of serotonin (5-HT) 2A and 2C receptors have differential effects on reversal learning. The present experiments investigated the effects of the 5-HT2A receptor antagonist, ketanserin and 5-HT2C receptor antagonist, SB242084 on acquisition and strategy-switching in a visual cue – response paradigm. Long-Evans rats were trained in a cross-maze to enter an arm based on color (visual cue version) or a specific turn response (response version). Systemic treatment with ketanserin did not affect initial learning of a visual cue or response discrimination, but ketanserin at 0.5 mg/kg significantly enhanced a switch between visual cue and response strategies. Ketanserin facilitated strategy-switching by inhibiting responses to a previously relevant strategy without affecting choices to never-reinforced strategies. Treatment with SB242084 (0.5, 1.0 or 2.0 mg/kg) did not affect acquisition of a visual cue or response discrimination. SB242084 treatment also did not affect strategy-switching. The present findings suggest that blockade of 5-HT2A, but not 5-HT2C, receptors enhance strategy switching.
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影响因子：
4.5
作者：
Chaudhry, IB;Soni, SD;Deakin, JFW
通讯作者：
Deakin, JFW
DOI：
10.1073/pnas.0711273105
发表时间：
2008-01-22
影响因子：
11.1
作者：
Bubenikova-Valesova, Vera;Stuchlik, Ales;Vales, Karel
通讯作者：
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影响因子：
14.5
作者：
Gu, Bon-Mi;Park, Ji-Young;Kwon, Jun Soo
通讯作者：
Kwon, Jun Soo
影响因子：
3.4
作者：
Dias, R;Aggleton, JP
通讯作者：
Aggleton, JP
影响因子：
2.7
作者：
Hunt, PR;Aggleton, JP
通讯作者：
Aggleton, JP