A biomechanical model for cell polarization and intercalation during Drosophila germband extension
A biomechanical model for cell polarization and intercalation during Drosophila germband extension
复制标题
果蝇种带延伸过程中细胞极化和嵌入的生物力学模型
DOI：
10.1088/1478-3975/12/5/056011
复制
发表时间：
2015
期刊：
影响因子：
2
通讯作者：
James J. Feng
中科院分区：
文献类型：
--
作者：
Haihan Lan;Qiming Wang;R. Fernandez;James J. Feng
果蝇发育过程中胚带延伸的特征是细胞沿着背腹（DV）轴合并，沿沿着前后（AP）轴分离。这种嵌入过程涉及平面单元极性、沿沿着单元边缘的各向异性收缩力以及协同的单元变形和运动。虽然先前的实验分别探讨了这些因素中的每一个，但它们之间的联系仍然不清楚。本文提出了一个化学力学模型，将这三个因素整合到一个连贯的框架。该模型预测的极化Rho激酶，肌球蛋白和巴祖卡下游的各向异性蘑菇分布。特别是肌球蛋白沿着DV轴沿着聚集在细胞边缘，导致它们收缩成顶点。随后，在顶点前后的细胞中的内侧肌球蛋白帮助将其拉长成平行于体轴的新边缘。因此，组织沿着AP轴延伸，并通过相邻交换在横向方向上变窄。模型预测的蛋白质和细胞和组织变形的极性与实验观察结果吻合得很好。
Germband extension during Drosophila development features the merging of cells along the dorsal–ventral (DV) axis and their separation along the anterior–posterior (AP) axis. This intercalation process involves planar cell polarity, anisotropic contractile forces along cell edges, and concerted cell deformation and movement. Although prior experiments have probed each of these factors separately, the connection among them remains unclear. This paper presents a chemo-mechanical model that integrates the three factors into a coherent framework. The model predicts the polarization of Rho-kinase, myosin and Bazooka downstream of an anisotropic Shroom distribution. In particular, myosin accumulates on cell edges along the DV axis, causing them to contract into a vertex. Subsequently, medial myosin in the cells anterior and posterior to the vertex helps to elongate it into a new edge parallel to the body axis. Thus, the tissue extends along the AP axis and narrows in the transverse direction through neighbor exchange. Model predictions of the polarity of the proteins and cell and tissue deformation are in good agreement with experimental observations.
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影响因子：
7.3
作者：
Vichas A;Zallen JA
通讯作者：
Zallen JA
影响因子：
7.5
作者：
Kasza, Karen E.;Zallen, Jennifer A.
通讯作者：
Zallen, Jennifer A.
Rho-kinase在果蝇轴伸长期间指导火箭筒/PAR-3平面极性。
影响因子：
11.8
作者：
Simoes, Sergio de Matos;Blankenship, J. Todd;Weitz, Ori;Farrell, Dene L.;Tamada, Masako;Fernandez-Gonzalez, Rodrigo;Zallen, Jennifer A.
通讯作者：
Zallen, Jennifer A.
影响因子：
11.8
作者：
Fernandez-Gonzalez R;Simoes Sde M;Röper JC;Eaton S;Zallen JA
通讯作者：
Zallen JA
果蝇种带延伸过程中的细胞嵌入及其对规则分割基因的调节。
DOI：
10.1242/dev.120.4.827
发表时间：
1994
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Irvine,KD;Wieschaus,E
通讯作者：
Wieschaus,E