Bifurcations: focal points of particle adhesion in microvascular networks.
Bifurcations: focal points of particle adhesion in microvascular networks.
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DOI：
10.1111/j.1549-8719.2011.00099.x
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Pant K
中科院分区：
文献类型：
--
作者：
Prabhakarpandian B;Wang Y;Rea-Ramsey A;Sundaram S;Kiani MF;Pant K
Particle adhesion in vivo is dependent on microcirculation environment which features unique anatomical (bifurcations, tortuosity, cross-sectional changes) and physiological (complex hemodynamics) characteristics. The mechanisms behind these complex phenomena are not well understood. In this study, we used a recently developed in vitro model of microvascular networks, called Synthetic Microvascular Network, for characterizing particle adhesion patterns in the microcirculation. Synthetic microvascular networks were fabricated using soft lithography processes followed by particle adhesion studies using avidin and biotin-conjugated microspheres. Particle adhesion patterns were subsequently analyzed using CFD based modeling. Experimental and modeling studies highlighted the complex and heterogeneous fluid flow patterns encountered by particles in microvascular networks resulting in significantly higher propensity of adhesion (>1.5X) near bifurcations compared to the branches of the microvascular networks. Bifurcations are the focal points of particle adhesion in microvascular networks. Changing flow patterns and morphology near bifurcations are the primary factors controlling the preferential adhesion of functionalized particles in microvascular networks. Synthetic microvascular networks provide an in vitro framework for understanding particle adhesion.
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影响因子：
6.1
作者：
Lim, D;Kamotani, Y;Takayama, S
通讯作者：
Takayama, S
影响因子：
2.4
作者：
Prabhakarpandian, B;Goetz, DJ;Kiani, MF
通讯作者：
Kiani, MF
影响因子：
3.4
作者：
Roth, NM;Sontag, MR;Kiani, MF
通讯作者：
Kiani, MF
DOI：
10.1111/j.1600-0463.2008.01148.x
发表时间：
2008-07
期刊：
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
影响因子：
--
作者：
Fukumura D;Jain RK
通讯作者：
Jain RK
影响因子：
3.4
作者：
Cromheecke, M;Piers, BA;Hoekstra, HJ
通讯作者：
Hoekstra, HJ