Zeolites: A series of promising biomaterials in bone tissue engineering.
Zeolites: A series of promising biomaterials in bone tissue engineering.
复制标题
沸石：骨组织工程中一系列有前景的生物材料
DOI：
10.3389/fbioe.2022.1066552
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发表时间：
2022
影响因子：
5.7
通讯作者：
Bao, Xingfu
中科院分区：
文献类型：
--
作者：
Li, Yue;Cai, Yanting;Chen, Tianyan;Bao, Xingfu
骨缺损是一个重要的世界性医学问题，它对患者的生理和心理造成了多种后果。临床上的一些治疗方法，包括植骨和肢体短缩，并不令人满意。近年来，骨组织工程被认为是治疗骨畸形的最有效的方法。与此同时，各种各样的生物材料也被合理地设计和创造出来，用于骨再生和组织修复。在众多优良的骨重建材料中，沸石基材料具有优良的骨诱导性，可作为骨重建的有效支架材料。此外，沸石的多孔性和高生物相容性赋予它们作为细胞粘附和增殖的理想基质的能力。更重要的是，沸石被研究作为植入物的潜在涂层材料，因为它们已被证明可以增加骨传导性并有助于局部弹性建模。最后但并非最不重要的是，沸石还可以用于治疗骨骼疾病，并在实际应用中作为膳食补充剂。因此，沸石的众多优点促使我们总结其最近的生物医学进展，包括但不限于显着的特点，广泛的分类，以及在骨组织工程中的应用前景。
As an important worldwide medical issue, bone defect exhibits a variety of physical and psychological consequences on sufferers. Some features of clinical treatments including bone grafting and limb shortening are not satisfactory. Recently, bone tissue engineering has been considered as the most effective approach to dealing with the issue of bone deformities. Meanwhile, a variety of biomaterials have been rationally designed and created for the bone regeneration and tissue repairing. Among all these admirable biomaterials for bone remodeling, zeolite-based materials can serve as efficient scaffold candidates with excellent osteo-inductivity. In addition, the porous nature and high biocompatibility of zeolites endow them with the ability as ideal substrates for cell adhesion and proliferation. More importantly, zeolites are investigated as potential coating materials for implants because they have been proven to increase osteo-conductivity and aid in local elastic modeling. Last but not least, zeolites can also be used to treat bone disorders and act as dietary supplements during the practical applications. Accordingly, numerous benefits of zeolite prompt us to summarize their recent biomedical progress including but not limited to the distinguishing characteristics, broad classifications, as well as promising usages in bone tissue engineering.
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