Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients.
Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients.
复制标题
新诊断的2型糖尿病患者中嗜中性粒细胞 - 淋巴细胞比与胰岛素抵抗之间的关系。
DOI：
10.1186/s12902-015-0002-9
复制
发表时间：
2015-03-02
影响因子：
2.7
通讯作者：
He L
中科院分区：
文献类型：
--
作者：
Lou M;Luo P;Tang R;Peng Y;Yu S;Huang W;He L
胰岛素抵抗 (IR) 在 2 型糖尿病 (T2DM) 的发病机制中起着至关重要的作用。 IR的机制可能与炎症有关，而中性粒细胞-淋巴细胞比值（NLR）是亚临床炎症的新指标。学者们很少研究IR与NLR之间的关系。本研究旨在评估 IR 和 NLR 之间的关系，并确定 NLR 是否是 IR 的可靠标记。该样本共有 413 名 T2DM 患者，其中 310 名患者的 HOMA-IR 值≥2.0。对照组由 130 名年龄和 BMI 匹配的健康受试者组成。糖尿病患者的NLR值显着高于健康对照者（P<0.001），且HOMA-IR值≥2.0的患者NLR值显着高于HOMA-IR值≤2.0的患者（P<0.001）。 Pearson相关分析显示NLR与HOMA-IR呈显着正相关（r = 0.285）（P < 0.001）。 Logistic回归分析显示，IR的风险预测因子包括NLR、TG和HbA1c。 NLR（P < 0.001，EXP(B) = 7.231，95% CI = 4.277–12.223）水平与IR呈正相关。 NLR 每增加一个单位，IR 优势比就会增加 7.231 倍（95% CI，4.277-12.223）。 NLR 增加与 IR 显着相关，高 NLR 值可能是 IR 的可靠预测标志。本文的在线版本 (doi:10.1186/s12902-015-0002-9) 包含补充材料，可供授权用户使用。
Insulin resistance (IR) plays a vital role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM). The mechanism of IR may be associated with inflammation, whereas the neutrophil-lymphocyte ratio (NLR) is a new indicator of subclinical inflammation. Scholars have rarely investigated the relationship between IR and NLR. This study aims to evaluate the relationship between IR and NLR, and determine whether or not NLR is a reliable marker for IR. The sample consists of a total of 413 patients with T2DM, 310 of whom have a HOMA-IR value of > 2.0. The control group consists of 130 age and BMI matched healthy subjects. The NLR values of the diabetic patients were significantly higher than those of the healthy control (P < 0.001), and the NLR values of the patients with a HOMA-IR value of > 2.0 are notably greater than those of the patients with a HOMA-IR value of ≤ 2.0 (P < 0.001). Pearson correlation analysis showed a significant positive correlation of NLR with HOMA-IR (r = 0.285) (P < 0.001). Logistic regression analysis showed that the risk predictors of IR include NLR, TG and HbA1c. NLR (P < 0.001, EXP(B) = 7.231, 95% CI = 4.277–12.223) levels correlated positively with IR. The IR odds ratio increased by a factor of 7.231 (95% CI, 4.277–12.223) for every one unit increase in NLR. Increased NLR was significantly associated with IR, and high NLR values may be a reliable predictive marker of IR. The online version of this article (doi:10.1186/s12902-015-0002-9) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
7.1
作者：
GORDON, ES
通讯作者：
GORDON, ES
影响因子：
5.3
作者：
Anuurad, Erdembileg;Tracy, Russell P.;Pearson, Thomas A.;Kim, Kyoungmi;Berglund, Lars
通讯作者：
Berglund, Lars
影响因子：
7.1
作者：
KELLEY, DE;SLASKY, BS;JANOSKY, J
通讯作者：
JANOSKY, J
影响因子：
3.5
作者：
Heianza, Y.;Arase, Y.;Sone, H.
通讯作者：
Sone, H.
影响因子：
4.8
作者：
Gibson, Patrick H.;Croal, Bernard L.;Hillis, Graham S.
通讯作者：
Hillis, Graham S.