Epithelial stem cells and implications for wound repair.
Epithelial stem cells and implications for wound repair.
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DOI：
10.1016/j.semcdb.2012.10.001
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发表时间：
2012-12
影响因子：
7.3
通讯作者：
Cotsarelis, George
中科院分区：
文献类型：
--
作者：
Plikus, Maksim V.;Gay, Denise L.;Treffeisen, Elsa;Wang, Anne;Supapannachart, Rarinthip June;Cotsarelis, George
关键词：
上皮干细胞的活化及其增殖后代的有效募集在皮肤伤口愈合中起着关键作用。再上皮化的伤口表皮由可追溯至表皮和几种类型的毛囊干细胞的后代组成。毛囊干细胞对伤口表皮的贡献特别有趣，因为它涉及从毛囊到表皮的谱系身份变化。来自我们实验室的研究表明，毛囊命运的隆突干细胞只承诺参与初始伤口再上皮化的瞬时扩增表皮后代，但最终被其他表皮克隆所击败，并在几个月后基本消失。相反，最近描述的位于毛囊峡部部分的干细胞群为伤口表皮提供了持久的后代，并且可以说，产生了新的毛囊间表皮干细胞。上皮干细胞在伤口愈合过程中的作用不仅限于再生复层表皮。通过研究大面积皮肤伤口的再生反应，我们的实验室发现伤口中心的上皮细胞可以获得更大的形态发生可塑性，并且与下面的伤口真皮一起，可以参与毛囊新生的胚胎样过程。未来的研究应该揭示这种显着的成人伤口再生现象的细胞和信号基础。
Activation of epithelial stem cells and efficient recruitment of their proliferating progeny plays a critical role in cutaneous wound healing. The reepithelialized wound epidermis hasa mosaic composition consisting of progeny that can be traced back both to epidermal and several types of hair follicle stem cells. The contribution of hair follicle stem cells to wound epidermis is particularly intriguing as it involves lineage identity change from follicular to epidermal. Studies from our laboratory show that hair follicle-fated bulge stem cells commit only transient amplifying epidermal progeny that participate in the initial wound re-epithelialization, but eventually are outcompeted by other epidermal clones and largely disappear after a few months. Conversely, recently described stem cell populations residing in the isthmus portion of hair follicle contribute long-lasting progeny toward wound epidermis and, arguably, give rise to new inter-follicular epidermal stem cells. The role of epithelial stem cells during wound healing is not limited to regenerating stratified epidermis. By studying regenerative response in large cutaneous wounds, our laboratory uncovered that epithelial cells in the center of the wound can acquire greater morphogenetic plasticity and, together with the underlying wound dermis, can engage in an embryonic-like process of hair follicle neogenesis. Future studies should uncover cellular and signaling basis of this remarkable adult wound regeneration phenomenon.
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影响因子：
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