Quantitative Assessment of Choroidal Thickness and Choroidal Vascular Features in Healthy Eyes Based on Image Binarization of EDI-OCT: A Single-Center Cross-Sectional Analysis in Chinese Population.
Quantitative Assessment of Choroidal Thickness and Choroidal Vascular Features in Healthy Eyes Based on Image Binarization of EDI-OCT: A Single-Center Cross-Sectional Analysis in Chinese Population.
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DOI：
10.3390/jcm12051911
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发表时间：
2023-02-28
影响因子：
3.9
通讯作者：
Li, Shuang
中科院分区：
文献类型：
--
作者：
Wang, Luping;Wang, Wei;Zhou, Zhuohua;Wang, Hao;Chakravarthy, Usha;Peto, Tunde;Casalino, Giuseppe;Wang, Kang;Li, Shuang
关键词：
目的：目的观察不同年龄和性别的健康人脉络膜血管结构的变化及脉络膜微结构的改变。研究方法：采用增强型深度成像光学相干断层扫描（EDI-OCT）分析黄斑中心凹下1500 μm范围内脉络膜的管腔面积、基质面积、脉络膜总面积、中心凹下脉络膜厚度（SFCT）、脉络膜血管指数（CVI）、脉络膜大血管层（LCVL）、脉络膜毛细血管-中脉络膜血管层（choriocapillaris-medium choroidal vessel layer）和LCVL/SFCT。我们分析了年龄和性别相关的变化，在中心凹下脉络膜结构。结果：1566例健康人1566只眼。受试者的平均年龄为43.62 ± 23.29岁，健康人的平均SFCT为269.30 ± 66.43 μm，LCVL/SFCT百分比为77.21 ± 5.84%，平均黄斑CVI为68.39 ± 3.15%。CVI在0-10岁组最大，随年龄增长而减小，最小值出现在>80岁组; LCVL/SFCT在0-10岁组最小，随年龄增长而增大，在>80岁组达到最大值。CVI与年龄呈显著负相关，LCVL/SFCT与年龄呈显著正相关。男性和女性之间无统计学显著差异。与SFCT相比，CVI的评分者间和评分者内可靠性变化较小。结论：脉络膜血管面积和CVI随年龄增长而减小，其中脉络膜毛细血管和脉络膜中血管的减少可能是脉络膜血管面积和CVI随年龄增长而减小的主要原因。性别对CVI无影响。与SFCT相比，健康人群的CVI显示出更好的一致性和可重复性。
Purpose: To quantify the structural changes in choroidal vessels and to observe choroid microstructural changes in different age and sex groups in a healthy Chinese population. Methods: Enhanced depth imaging optical coherence tomography (EDI-OCT) was employed to analyze the luminal area, stromal area, total choroidal area, subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), large choroidal vessel layer (LCVL), choriocapillaris–medium choroidal vessel layer, and LCVL/SFCT of the choroid in the subfoveal macular area within 1500 μm of the macula. We analyzed the age- and sex-related changes in the subfoveal choroidal structure. Results: A total of 1566 eyes from 1566 healthy individuals were included. The mean age of the participants was 43.62 ± 23.29 years, the mean SFCT of healthy individuals was 269.30 ± 66.43 μm, LCVL/SFCT percentage was 77.21 ± 5.84%, and the mean macular CVI was 68.39 ± 3.15%. CVI was maximum in the 0–10 years group, decreasing with age, and the lowest values occurred in the >80 years group; LCVL/SFCT was the lowest in the 0–10 years group, increasing with age and reaching a maximum in the >80 years group. CVI showed a significant negative correlation with age, and LCVL/SFCT showed a significant positive correlation with age. There was no statistically significant difference between males and females. Interrater and intrarater reliability was less variable with CVI than with SFCT. Conclusions: The choroidal vascular area and CVI decreased with age in the healthy Chinese population, of which the age-related decrease in vascular components maybe dominated by the decrease in choriocapillaris and medium choroidal vessels. Sex had no effect on CVI. The CVI of healthy populations showed better consistency and reproducibility when compared with SFCT.
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影响因子：
13.7
作者：
Branchini LA;Adhi M;Regatieri CV;Nandakumar N;Liu JJ;Laver N;Fujimoto JG;Duker JS
通讯作者：
Duker JS
DOI：
10.1097/iae.0b013e3181be0a83
发表时间：
2009-11-01
影响因子：
3.3
作者：
Imamura, Yutaka;Fujiwara, Takamitsu;Spaide, Richard F.
通讯作者：
Spaide, Richard F.
DOI：
10.1097/iae.0000000000001347
发表时间：
2017-07-01
影响因子：
3.3
作者：
Ruiz-Medrano, Jorge;Flores-Moreno, Ignacio;Ruiz-Moreno, Jose M.
通讯作者：
Ruiz-Moreno, Jose M.
影响因子：
3.7
作者：
Wakatsuki Y;Shinojima A;Kawamura A;Yuzawa M
通讯作者：
Yuzawa M
影响因子：
4.3
作者：
Dou N;Yu S;Tsui CK;Yang B;Lin J;Lu X;Xu Y;Wu B;Zhao J;Liang X
通讯作者：
Liang X