The Evolutionary Dynamics of the Odorant Receptor Gene Family in Corbiculate Bees.
The Evolutionary Dynamics of the Odorant Receptor Gene Family in Corbiculate Bees.
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DOI：
10.1093/gbe/evx149
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发表时间：
2017-08-01
影响因子：
3.3
通讯作者：
Ramírez SR
中科院分区：
文献类型：
--
作者：
Brand P;Ramírez SR
昆虫依靠化学信息来寻找食物、选择配偶和检测潜在的捕食者。据推测，嗅觉系统的适应性变化促进了许多昆虫谱系的多样化。例如，气味受体（OR）基因的进化变化通常与生活史策略的改变同时发生。珊瑚蜂表现出通过嗅觉控制的多种行为，包括不同程度的社会组织以及与花卉资源的多种关联。在这里，我们研究了驱动 Corbiculate 蜜蜂 OR 基因家族与其他化学感应基因家族相比进化的分子机制。我们的结果表明，尽管蜜蜂谱系的库大小发生了重大变化，但 OR 基因家族的基因组组织在 ~80 Myr 中仍然高度保守。此外，OR基因的进化似乎主要是由含有大量OR基因的少数基因组区域中的谱系特异性基因重复驱动的。选择分析表明，OR 基因在正选择下进化，在最近复制的拷贝中检测到最强的信号。我们的结果表明，染色体易位对 OR 进化的影响很小，相反，局部分子机制似乎是 OR 库大小的主要驱动因素。我们的结果为长期存在的假设提供了实证支持，即正选择塑造了 OR 基因家族的多样化。总之，我们的结果为昆虫嗅觉进化的分子机制提供了新的线索。
Insects rely on chemical information to locate food, choose mates, and detect potential predators. It has been hypothesized that adaptive changes in the olfactory system facilitated the diversification of numerous insect lineages. For instance, evolutionary changes of Odorant Receptor (OR) genes often occur in parallel with modifications in life history strategies. Corbiculate bees display a diverse array of behaviors that are controlled through olfaction, including varying degrees of social organization, and manifold associations with floral resources. Here we investigated the molecular mechanisms driving the evolution of the OR gene family in corbiculate bees in comparison to other chemosensory gene families. Our results indicate that the genomic organization of the OR gene family has remained highly conserved for ∼80 Myr, despite exhibiting major changes in repertoire size among bee lineages. Moreover, the evolution of OR genes appears to be driven mostly by lineage-specific gene duplications in few genomic regions that harbor large numbers of OR genes. A selection analysis revealed that OR genes evolve under positive selection, with the strongest signals detected in recently duplicated copies. Our results indicate that chromosomal translocations had a minimal impact on OR evolution, and instead local molecular mechanisms appear to be main drivers of OR repertoire size. Our results provide empirical support to the longstanding hypothesis that positive selection shaped the diversification of the OR gene family. Together, our results shed new light on the molecular mechanisms underlying the evolution of olfaction in insects.
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影响因子：
3.9
作者：
Bielawski, JP;Yang, ZH
通讯作者：
Yang, ZH
影响因子：
3.4
作者：
Brand P;Ramírez SR;Leese F;Quezada-Euan JJ;Tollrian R;Eltz T
通讯作者：
Eltz T
影响因子：
4.9
作者：
Eyres I;Duvaux L;Gharbi K;Tucker R;Hopkins D;Simon JC;Ferrari J;Smadja CM;Butlin RK
通讯作者：
Butlin RK
影响因子：
16.2
作者：
Dobritsa, AA;van der Goes van Naters, W;Carlson, JR
通讯作者：
Carlson, JR
影响因子：
3.8
作者：
Engsontia, Patamarerk;Sanderson, Alan P.;Brown, Stephen
通讯作者：
Brown, Stephen